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. 2020 Nov 6;143(12):3827–3841. doi: 10.1093/brain/awaa317

Figure 4.

Figure 4

Axial T1-weighted MRI of the semantic dementia patient carrying somatic variant R42H, showing profound leftsided temporal atrophy 3 years after disease onset. Pathological examination 15 years after disease onset showed atrophy of both temporal poles. The middle image is from a patient without a somatic variant (4 years after onset) showing atrophy of both temporal lobes. Right: A patient with the germline (p.I383V) TARDBP variant, showing a similar atrophy pattern bilaterally (4 years after onset).