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. 2021 Jan 1;11(6):2594–2611. doi: 10.7150/thno.51648

Figure 2.

Figure 2

Deficiency of endogenous ILCs develops exacerbated cardiac fibrosis following injury. (A) BALB/cByJ, Rag2-/-, and Rag2-/-IL2Rγc -/- mice were subcutaneously administered saline or isoproterenol (ISO, 30 mg/kg per day for 3 days). The cardiac tissues were collected for histological analysis on day 4 after the last injection. Representative images of Picrosirius red staining for fibrotic area are shown. Scale bar = 50 µm. (B) Quantification of fibrosis area to assess susceptibility to isoproterenol (ISO)-induced cardiac fibrosis. Data are pooled from two independent experiments and expressed as the mean ± SD (n = 5-9 per group). (C) Picrosirius red staining for fibrotic area. (D) Quantification of fibrosis area. *P < 0.05, **P < 0.01 by one-way ANOVA followed by the Bonferroni multiple comparison post-hoc test. All values are means ± SD. Each dot indicates a biological replicate.