The authors regret that errors were present in Table 1 of the above article. The correct version of Table 1 appears below:
Table 1 Physicochemical characteristics of local anaesthetics.3−5 MW, molecular weight.
Structural classification | MW | pKa | Protein binding (%) | Partition coefficient | Onset | Elimination half-life (min) | Maximum dose without vasoconstrictor (mg kg−1) | Maximum dose with vasoconstrictor (mg kg−1) | |
---|---|---|---|---|---|---|---|---|---|
Cocaine | Ester | 303 | 8.6 | 95 | – | Fast | 100 | 1.5 (topical) | – |
Chloroprocaine | Ester | 271 | 9.1 | – | 17 | Fast | 6 | 11 | 14 |
Prilocaine | Amide | 220 | 7.7 | 55 | 50 | Fast | 100 | 6 | 8 |
Lidocaine | Amide | 234 | 7.8 | 70 | 110 | Fast | 100 | 3 | 7 (9 for airway topicalisation) |
Mepivacaine | Amide | 246 | 7.7 | 77 | 42 | Fast | 115 | 5 | 7 |
Bupivacaine | Amide | 288 | 8.1 | 95 | 560 | Moderate | 210 | 2 | 2 |
Ropivacaine | Amide | 274 | 8.1 | 94 | 230 | Moderate | 120 | 3 | 3 |
Levobupivacaine | Amide | 288 | 8.1 | 95 | – | Moderate | 210 | 2 | 2 |
The authors would like to apologise for any inconvenience caused.