In Zuurbier et al, 1 the published article contains errors in Table 1. The correct table is shown below. The authors confirm all results, conclusions of this article remain unchanged.
TABLE 1.
FAO inhibitors for IRI
| Compound | Mechanism/target | Activity in models of MI | Model | Ref |
|---|---|---|---|---|
| sulfo‐N‐succinimidyl oleate (SSO) | Inhibition of sarcolemmal FAT/CD36 | Prevented cardiac dysfunction after ischaemia | Isolated diabetic and control male Wistar rat harts | [161] |
|
CBM‐301940 CBM‐300864 |
Inhibition of malonyl CoA decarboxylase | Improved cardiac function during and after ischaemia |
Isolated rat hearts Pigs in vivo |
[162, 163] |
| Methyl‐GBB | decreased accumulation of long‐chain acylcarnitines | Decreased MI size, improved survival |
ligation of LAD, rats Isolated perfused rat hearts |
[164] |
| Trimetazidine |
long‐chain 3‐ketoacyl‐CoA thiolase inhibitor AMPK and ERK signalling pathways |
Reduced MI size and oxidative stress | in vivo regional ischaemia and reperfusion, mice | [165] |
| carvedilol | adrenergic receptor blocker; modulator of cardiac AMPK signalling pathway | MI size reduction, improved cardiac functions | ligation of LAD, mice | [166] |
Abbreviations: LAD, left anterior descending coronary artery; MI, myocardial infarction.
REFERENCE
- 1. Zuurbier CJ, Bertrand L, Beauloye CR, et al. Cardiac metabolism as a driver and therapeutic target of myocardial infarction. J Cell Mol Med. 2020;24:5937‐5954. 10.1111/jcmm.15180 [DOI] [PMC free article] [PubMed] [Google Scholar]
