Table 2.
The multiplication interactive effects of 25(OH)D3, 25(OH)D2, or total 25(OH)D and testosterone on IFG and T2DM.
| Variables | Male ORs (95% CIs) | Female ORs (95% CIs) | ||||
|---|---|---|---|---|---|---|
| Vitamin D | Ln-Testosterone | p for Interaction | Vitamin D | Ln-Testosterone | p for Interaction | |
| IFG | ||||||
| 25(OH)D3 | 0.97 (0.95, 0.99) * | - | - | 0.99 (0.98, 1.01) | - | - |
| 25(OH)D2 | 0.83 (0.78, 0.88) * | - | - | 0.86 (0.82, 0.90) * | - | - |
| 25(OH)D | 0.95 (0.93, 0.97) * | - | - | 0.98 (0.96, 0.99) * | - | - |
| Ln-testosterone | - | 0.82 (0.63, 1.10) | - | - | 1.12 (0.99, 1.28) | - |
| 25(OH)D3 + Ln-testosterone | 0.97 (0.95, 0.99) * | 0.87 (0.66, 1.13) | - | 1.00 (0.98, 1.01) | 1.12 (0.99, 1.28) | - |
| 25(OH)D2 + Ln-testosterone | 0.83 (0.78, 0.88) * | 0.90 (0.69, 1.17) | - | 0.86 (0.81, 0.90) * | 1.15 (1.01, 1.31) * | - |
| 25(OH)D + Ln-testosterone | 0.95 (0.94, 0.97) * | 0.92 (0.70, 1.20) | - | 0.98 (0.96, 0.99) * | 1.12 (0.98, 1.28) | - |
| 25(OH)D3 + Ln-testosterone + 25(OH)D3 × Ln-testosterone | 0.98 (0.95, 1.02) | 1.10 (0.47, 2.58) | 0.559 | 0.95 (0.90, 1.01) | 1.57 (1.02, 2.42) | 0.109 |
| 25(OH)D2 + Ln-testosterone + 25(OH)D2 × Ln-testosterone | 0.82 (0.74, 0.90) * | 0.77 (0.29, 2.01) | 0.739 | 0.91 (0.79, 1.06) | 0.97 (0.66, 1.44) | 0.370 |
| 25(OH)D + Ln-testosterone + 25(OH)D × Ln-testosterone | 0.96 (0.92, 0.99) * | 0.98 (0.33, 2.95) | 0.906 | 0.95 (0.90, 1.00)* | 1.51 (0.91, 2.50) | 0.224 |
| T2DM | ||||||
| 25(OH)D3 | 0.98 (0.96, 1.01) | - | - | 1.00 (0.98, 1.02) | - | - |
| 25(OH)D2 | 0.82 (0.77, 0.88) * | - | - | 0.86 (0.81, 0.90) * | - | - |
| 25(OH)D | 0.96 (0.94, 0.98) * | - | - | 0.98 (0.97, 1.00) * | - | - |
| Ln-testosterone | - | 0.76 (0.58, 1.00) | - | - | 1.61 (1.38, 1.87) * | - |
| 25(OH)D3 + Ln-testosterone | 0.99 (0.96, 1.01) | 0.78 (0.59, 1.03) | - | 1.01 (0.99, 1.03) | 1.61 (1.38, 1.88) * | - |
| 25(OH)D2 + Ln-testosterone | 0.83 (0.77, 0.88) * | 0.82 (0.62, 1.09) | - | 0.85 (0.81, 0.90) * | 1.62 (1.38, 1.89) * | - |
| 25(OH)D + Ln-testosterone | 0.97 (0.95, 0.99) * | 0.82 (0.62, 1.09) | - | 0.99 (0.97, 1.00) | 1.60 (1.37, 1.86) * | - |
| 25(OH)D3 + Ln-testosterone + 25(OH)D3 × Ln-testosterone | 0.99 (0.95, 1.02) | 0.85 (0.37, 1.98) | 0.838 | 0.96 (0.90, 1.02) | 2.51 (1.45, 4.37) * | 0.099 |
| 25(OH)D2 + Ln-testosterone + 25(OH)D2 × Ln-testosterone | 0.81 (0.73, 0.90) * | 0.64 (0.25, 1.65) | 0.582 | 0.66 (0.55, 0.79) * | 3.14 (1.99, 4.96) * | 0.002 |
| 25(OH)D + Ln-testosterone + 25(OH)D × Ln-testosterone | 0.96 (0.93, 0.99) * | 0.68 (0.24, 1.95) | 1.006 | 0.93 (0.88, 0.98) * | 3.14 (1.68, 5.88) * | 0.028 |
Adjusted for smoking status, alcohol intake, physical activity, average monthly individual income, level of education, BMI, SBP, PP, TC, TG, HDL-C, LDL-C and a family history of T2DM. * p < 0.05. Abbreviations: IFG, impaired fasting glucose; OR, odds ratio; T2DM, type 2 diabetes mellitus; 95%CI: 95% confidence interval.