Table 1.
Composition ratio of components in NSCs (%, w/w).
| DUT | TPGS | GCC | PGL | Carrier * | L:C | |
|---|---|---|---|---|---|---|
| NSC-01 | 1 | 5 | 5 | - | 10 | 1:1 |
| NSC-02 | 1 | 10 | 10 | - | 30 | 2:3 |
| NSC-03 | 1 | 20 | 20 | - | 30 | 4:3 |
| NSC-04 | 1 | 25 | 25 | - | 30 | 5:3 |
| NSC-05 | 1 | 20 | - | 20 | 30 | 4:3 |
| NSC-06 | 1 | 40 | - | - | 30 | 4:3 |
| NSC-07 | 1 | - | - | - | 30 | - |
| Physical mixture-07 | 1 | - | - | - | 30 | - |
* Carrier: Neusilin® US2 (Magnesium aluminometasilicate). Abbreviations: DUT, dutasteride; TPGS, D-α tocopheryl polyethylene glycol 1000 succinate; GCC, glyceryl caprylate/caprate; PGL, propylene glycol monolaurate; L:C, Lipid:Carrier; NSC, nanoporous silica entrapped lipid-drug complex.