Table 5.
Pharmacokinetic parameters of dutasteride after a single oral administration of NSC tablets and Avodart® soft capsules in beagle dogs. All data are expressed as mean ± standard deviation (S D), n = 12.
| NSC Tablets | Avodart® | 90% CI 4 | |
|---|---|---|---|
| AUCt 1 (ng·h/mL) | 2940.3 ± 1036.2 | 2843.7 ± 1106.9 | 0.8641, 1.0454 |
| Relative BA, % (to the Avodart®) |
103.4% | - | - |
| Cmax 2 (ng/mL) | 67.60 ± 16.37 | 63.73 ± 23.75 | 0.8132, 1.0024 |
| Tmax 3 (h) | 1.79 ± 1.50 | 1.75 ± 2.03 | - |
1 AUCt: area under the plasma concentration–time curve to the last sampling time. 2 Cmax: maximum plasma concentration. 3 Tmax: time to Cmax. 4 CI: confidence interval.