Table 3.
Relative frequencies, medians and interquartile range (IQR) of the most abundant bacterial phyla and genera detected in CVL samples from fertile women (Control group), women with a history of repetitive abortion (RA group), and women with infertility of unknown origin (INF group).
| Control (n = 14) | RA (n = 21) | INF (n = 23) | |||||
|---|---|---|---|---|---|---|---|
| Phylum Genus |
n (%) 1 |
Median (IQR) |
n (%) |
Median (IQR) |
n (%) |
Median (IQR) |
p-Value 2 |
| Firmicutes | 14 (100) |
99.60 (99.18–99.80) |
21 (100) |
97.29 (72.34–99.35) |
23 (100) |
89.96 (52.46–98.85) |
0.001 |
| Lactobacillus | 14 (100) |
97.88 (96.92–99.31) |
21 (100) |
93.49 (67.18–97.53) |
23 (100) |
71.95 (0.76–94.09) |
0.001 |
| Staphylococcus | 13 (93) |
0.31 (0.11–0.66) |
19 (90) |
0.45 (0.03–1.51) |
22 (96) |
0.75 (0.14–5.40) |
0.260 |
| Streptococcus | 9 (64) |
0.02 (<0.01–0.03) |
14 (67) |
0.01 (<0.01–0.34) |
16 (70) |
0.06 (<0.01–2.04) |
0.180 |
| Finegoldia | 13 (93) |
0.17 (0.03–0.28) |
18 (86) |
0.16 (0.07–0.61) |
17 (74) |
0.12 (0.02–1.24) |
0.760 |
| Peptoniphilus | 11 (79) |
0.06 (0.01–0.21) |
16 (76) |
0.10 (0.02–0.49) |
17 (74) |
0.09 (<0.01–1.45) |
0.670 |
| Enterococcus | 2 (14) |
<0.01 (<0.01–<0.01) |
6 (29) |
<0.01 (<0.01–0.04) |
12 (52) |
0.01 (<0.01–0.19) |
0.044 |
| Anaerococcus | 11 (79) |
0.03 (0.01–0.16) |
18 (86) |
0.10 (0.05–0.30) |
18 (78) |
0.12 (0.01–1.71) |
0.220 |
| Actinobacteria | 12 (86) |
0.09 (0.02–0.20) |
21 (100) |
0.32 (0.08–7.87) |
23 (100) |
4.84 (0.1–34.36) |
0.012 |
| Gardnerella | 4 (29) |
<0.01 (<0.01–0.01) |
11 (52) |
0.01 (<0.01–0.12) |
9 (39) |
<0.01 (<0.01–0.04) |
0.300 |
| Bifidobacterium | 3 (21) |
<0.01 (<0.01–<0.01) |
9 (43) |
<0.01 (<0.01–0.07) |
9 (39) |
<0.01 (<0.01–0.03) |
0.300 |
| Atopobium | 2 (14) |
<0.01 (<0.01–<0.01) |
7 (33) |
<0.01 (<0.01–0.01) |
13 (57) |
0.02 (<0.01–0.12) |
0.015 |
| Proteobacteria | 1 (93) |
0.07 (0.02–0.10) |
21 (100) |
0.28 (0.09–0.69) |
22 (96) |
0.23 (0.09–0.64) |
0.003 |
| Escherichia/Shigella | 1 (7) |
<0.01 (<0.01–<0.01) |
9 (43) |
<0.01 (<0.01–0.02) |
8 (35) |
<0.01 (<0.01–0.01) |
0.084 |
| Bacteroidetes | 10 (71) |
0.03 (<0.01–0.08) |
18 (86) |
0.16 (0.06–1.33) |
22 (96) |
0.80 (0.05–3.19) |
0.006 |
| Prevotella | 8 (57) |
0.02 (<0.01–0.08) |
15 (71) |
0.06 (<0.01–0.45) |
19 (83) |
0.70 (0.01–2.55) |
0.660 |
| Tenericutes | 6 (43) |
<0.01 (<0.01–0.16) |
5 (24) |
<0.01 (<0.01–<0.01) |
10 (43) |
<0.01 (<0.01–0.97) |
0.290 |
| Minor phyla | 14 (100) |
0.13 (0.07–0.18) |
21 (100) |
0.16 (0.07–0.65) |
23 (100) |
0.17 (0.09–1.29) |
0.280 |
| Minor genera | 14 (100) |
0.30 (0.09–0.70) |
21 (100) |
0.91 (0.27–2.54) |
23 (100) |
2.26 (0.40–8.35) |
0.038 |
| Unclassified_genera | 14 (100) |
0.09 (0.05–0.12) |
21 (100) |
0.13 (0.07–0.66) |
23 (100) |
0.14 (0.04–0.36) |
0.170 |
1n (%): Number of samples in which the phylum/genus was detected (relative frequency of detection). 2 Kruskal–Wallis rank tests with Bonferroni correction.