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. 2021 Jan 6;13(1):159. doi: 10.3390/nu13010159

Figure 3.

Figure 3

Nonesterified fatty acid (NEFA) kinetics in the subcutaneous adipose tissue of healthy subjects after a mixed meal given at 08:00, following overnight fasting. At the beginning of the meal (0 time), the trans-capillary flow of NEFA is from the adipocytes to the bloodstream (A). The rates of NEFA release (B), lipolysis (C), and plasma levels of NEFA (D) are all increased to cover energy requirements in muscle during sleep and sustain endogenous glucose production. Within 30 min after the beginning of the meal and in the presence of increasing blood levels of insulin, trans-capillary flow of NEFA is reversed from the bloodstream to the adipocytes (A). The rates of NEFA release (B), lipolysis (C), and plasma levels of NEFA (D) are all rapidly suppressed to allow: (a) storage of the ingested lipids in the adipose tissue; (b) suppression of endogenous glucose production by the liver and kidneys and initiation of glucose storage in the liver; (c) stimulation of glucose uptake in skeletal muscle (data from [149]).