Figure 8.

The upstream regulator network for NFE2L2 (nuclear factor (erythroid-derived 2)-like 2) for wooden breast (WB) myopathy (activation Z score = 2.18, 4.3 × 10⁻⁹) compared to normal muscle (A) and for the high vs. low PedM broiler feed efficiency (FE) proteomic data (activation Z score = 2.38, p = 1.54 × 10⁻⁶) (B). Overlay of the FE data on the WB myopathy data (C) and vice versa (D) both resulted in predicted activations of NFE2L2. Protein abbreviations in B and D in the FE data set are as follows: ARF1 (ADP-ribosylation factor 1), COX4I1 (cytochrome oxidase subunit IV isoform 1), EIF4G2 (eukaryotic translation initiation factor 4 gamma 2), GPX1 (glutathione peroxidase 1), PPIB (peptidylprolyl isomerase B (cyclophilin B), PSMB1 (proteosome 26S subunit beta type, 1) PSMD1 (proteosome 26S subunit non-ATPase, 1), RYR3 (ryanodine receptor 3), SOD1 (superoxide dismutase 1), UGDH (UDP-glucose 6-dehydrogenase).