Author response image 1. Deletion of Runx2 in CNC-derived cells gives rise to hard tissue defects in Osr2-Cre;Runx2^fl/fl mice.

(A-C) Isolated palatine bones and sphenoid bones from control (A), Osr2-Cre;Runx2^fl/fl (B) and Osr2-Cre;Runx2^fl/fl;Twist1^fl/+ mice (C). Red dashed lines outline the pterygoid plate. Blue dashed lines outline the pterygoid plate. (D) Quantification of the size (length, width and height) of the palatine bone and of the pterygoid plate (length and height) from control (red bars), Osr2-Cre;Runx2^fl/fl (blue bars) and Osr2-Cre;Runx2^fl/fl;Twist1^fl/+ (yellow bars) mice (N=2). Scale bars in A-C: 0.6 mm.