Figure 3.

ROR2 signaling. Binding of a non-canonical WNT ligand induces the association of ROR2 with a FZD receptor (e.g., FZD2, 5, 7), or other WNT co-receptors (e.g., PTK7, ROR1). ROR2 activation is triggered by its interplay with several kinases (orange). The signal is then relayed to downstream pathways including WNT/PCP (magenta), PI3K/AKT (green), or MAPK/ERK (brown). Active WNT/ROR2 signaling results in the nuclear translocation and activation of transcription factors (blue) that mediate the expression of target genes associated with cell proliferation, survival, or EMT.