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. 2021 Jan 12;10(1):141. doi: 10.3390/cells10010141

Figure 4.

Figure 4

(A). HIF-1α and HIF-2α expression in non-small cell lung cancer (NSCLC) tumors. (B). Survival analysis of lung adenocarcinoma (LUAD, n = 500) and lung squamous cell carcinoma (LUSC, n = 494) patients. Median expression refers to the median FPKM value calculated based on the gene expression (FPKM) data from all patients in this dataset. Expression cut-off: based on the FPKM value of each gene, patients were classified into two groups, and association between survival and gene expression (FPKM) was examined. The best expression cut-off refers the FPKM value that yields maximal difference with regard to survival between the two groups at the lowest log-rank P-value. P score: Log-rank P value for Kaplan–Meier plot showing results from analysis of correlation between mRNA expression level and patient survival. Five-year survival for patients with higher or lower expression than the expression cut-off. (C). Expression of HIF-1α and HIF-2α in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) tumor tissue derived from patients and healthy controls. All data presented in Figure 3 were collected from The Human Protein Atlas version 20.0 database [33,34].