Table 5.
Particle size, polydispersity index (PDI), and zeta potential of optimized nanosuspensions stabilized in the mixture of Kollidon® VA and Kollidon® K12 along with one of Lutrol® F127, hydroxypropyl β-cyclodextrin (HPβCD), polyethylene glycol (PEG) 6000 or sodium lauryl sulfate (SLS).
| Formulations | Concentration (%, w/v) | Particle Size (nm) (Mean ± SD) | PDI (Mean ± SD) |
Zeta Potential (mV) |
|
|---|---|---|---|---|---|
| F1 | Kollidon® VA/Kollidon® K12/Lutrol® F127 | 1.0/0.5/1.0 | 54.9 ± 1.8 | 0.29 ± 0.03 | −35.2 ± 1.6 |
| F2 | Kollidon® VA/Kollidon® K12/HPβCD | 1.0/0.5/1.0 | 43.0 ± 0.6 | 0.27 ± 0.01 | −43.0 ± 2.3 |
| F3 | Kollidon® VA/Kollidon® K12/PEG 6000 | 1.0/0.5/1.0 | 53.1 ± 1.4 | 0.31 ± 0.02 | −34.5 ± 1.8 |
| F4 | Kollidon® VA/Kollidon® K12/SLS | 1.0/0.5/0.1 | 120.1 ± 2.2 | 0.33 ± 0.02 | −40.1 ± 2.1 |