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. 2021 Jan 13;26(2):399. doi: 10.3390/molecules26020399

Table 2.

IC50 values of alkaloids, chalcones and isothiocyanates in SK-LU-1 and HLCSC.

IC50 Values (mean ± SD)
Phytochemical Category Phytochemical Compound SK-LU-1
24 h 48 h 72 h
μg/mL μM μg/mL μM μg/mL μM
Isothiocyanate BI 3.96 ± 0.27 26.54 ± 1.80 4.54 ± 1.35 30.39 ± 9.05 4.99 ± 1.04 33.41 ± 6.97
PI 2.68 ± 0.01 16.39 ± 0.04 2.69 ± 0.00 16.48 ± 0.00 2.81 ± 0.04 17.18 ± 0.22
Chalcone LICO 12.75 ± 0.38 37.68 ± 1.13 13.96 ± 1.41 41.24 ± 4.16 16.28 ± 1.79 48.09 ± 5.29
ISO 10.93 ± 2.28 42.63 ± 8.91 16.73 ± 0.40 65.29 ± 1.55 17.11 ± 0.79 66.75 ± 3.06
Alkaloid EVO 5.71 ± 0.69 18.81 ± 2.26 5.41 ± 1.06 17.83 ± 3.50 4.33 ± 0.36 14.26 ± 1.19
CHE 4.32 ± 0.21 12.21 ± 0.58 2.86 ± 0.55 8.09 ± 1.56 2.74 ± 0.47 7.74 ± 1.34
Positive control SAL 10.40 ± 2.33 13.84 ± 3.10 9.96 ± 1.10 13.26 ± 1.46 10.18 ± 0.33 13.56 ± 0.43
Phytochemical Category Phytochemical Compound HLCSC
24 h 48 h 72 h
μg/mL μM μg/mL μM μg/mL μM
Isothiocyanate BI 2.88 ± 0.24 19.30 ± 1.61 2.80 ± 0.11 18.73 ± 0.71 3.14 ± 0.23 21.04 ± 1.52
PI 5.14 ± 0.20 31.49 ± 1.21 6.10 ± 0.07 37.37 ± 0.43 6.27 ± 0.16 38.38 ± 1.00
Chalcone LICO 8.27 ± 1.49 24.42 ± 4.41 8.65 ± 0.63 25.55 ± 1.86 12.01 ± 0.59 35.49 ± 1.76
ISO 22.25 ± 0.67 86.81 ± 2.62 23.01 ± 0.12 89.76 ± 0.47 23.52 ± 0.45 91.77 ± 1.74
Alkaloid EVO 4.71 ± 1.49 15.53 ± 4.90 7.72 ± 0.72 25.45 ± 2.38 9.13 ± 0.54 30.10 ± 1.77
CHE 8.2 ± 0.44 23.21 ± 1.24 7.86 ± 0.04 22.23 ± 0.10 12.57 ± 2.72 35.57 ± 7.68
Positive control SAL 3.46 ± 0.35 4.61 ± 0.47 4.42 ± 1.90 5.89 ± 2.52 2.57 ± 0.38 3.42 ± 0.50