Table 1.

Summary of antigen-specific B cell therapies to date.

Disease Model	Method	Results	References
Hemophilia	tNPs coated with FVIII and CD22 ligands	FVIII-specific B cell deletion	[20]
	tNP with FVIII encapsulated with rapamycin	FVIII-specific B cell deletion	[12]
	FVIII-BAR Treg	FVIII-specific B cell tolerance and antibody suppression	[27]
	FVIII-BAR CD8+ T cell	FVIII-specific B cell deletion	[30]
EAE	Soluble antigen array with PLP + LABL	PLP-reactive B cell anergy	[21,23]
Pemphigus Vulgaris	Dsg3-CAAR T cell	Dsg3-specific B cell deletion	[33,34]
Autoimmune diabetes	Soluble antigen array with insulin + LABL	Insulin-specific B cell anergy ex vivo	[24]
	287-CAR CD8+ T cell	I-Ag7-B:9–23 presenting APC deletion	[27]
	mab123	Insulin-binding B cell deletion	[35]
	Fc-insulin fusion protein (AKS-107)	Insulin-binding B cell deletion/anergy	unpublished
	Insulin-toxin	Insulin-binding B cell deletion	unpublished