Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic model of SFN-mediated anti-osteoclastogenesis. SFN inhibits the phosphorylation of JNK, decreasing the expression levels of autophagic proteins (Atg5, Atg12, Beclin1, and LC3). Subsequently, the level of osteoclastic autophagy is attenuated, which consequently suppresses osteoclastogenesis and bone erosion.
