The content is available as a PDF (9.3 MB).
Biography
Biographical note of the first author: XU Xiao Gang, male, born in 1984, PhD, Assistant Research Fellow, majoring in immunology and geriatrics.
Footnotes
This work was supported by grants from National Natural Science Foundation of China [No.31702144, 81771520, and 31700734]; Science Technology Department of Zhejiang Province [No.2016C34002]; Zhejiang Provincial Natural Science Foundation [NO. LQ20H250002].
References
- 1.Wang C, Horby PW, Hayden FG. A novel coronavirus outbreak of global health concern. Lancet. 2020;395:470–473. doi: 10.1016/S0140-6736(20)30185-9. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2.Sohrabi C, Alsafi Z, O'Neill N. World health organization declares global emergency: a review of the 2019 novel coronavirus (COVID-19) Int J Surg. 2020;76:71–76. doi: 10.1016/j.ijsu.2020.02.034. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 3.Chan JF, Yuan S, Kok KH. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet. 2020;395:514–523. doi: 10.1016/S0140-6736(20)30154-9. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 4.Hoffmann M, Kleine-Weber H, Schroeder S. SARS-CoV-2 cell entry depends on ACE2 and tmprss2 and is blocked by a clinically proven protease inhibitor. Cell. 2020;181:271–280. doi: 10.1016/j.cell.2020.02.052. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 5.Jun Lan, Jiwan Ge, Jinfang Yu. Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor. Nature. 2020;581:215–220. doi: 10.1038/s41586-020-2180-5. [DOI] [PubMed] [Google Scholar]
- 6.Yu P, Qi F, Xu Y. Age-related rhesus macaque models of COVID-19. Animal Model Exp Med. 2020;3:93–97. doi: 10.1002/ame2.12108. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 7.Cava C, Bertoli G, Castiglioni I. In silico discovery of candidate drugs against COVID-19. Viruses. 2020:12. doi: 10.3390/v12040404. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 8.Wang K, Chen W, Zhou Y-S. SARS-CoV-2 invades host cells via a novel route: Cd147-spike protein. bioRxiv. 2020 doi: 10.1038/s41392-020-00426-x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 9.Sigrist CJ, Bridge A, Le Mercier P. A potential role for integrins in host cell entry by SARS-CoV-2. Antiviral Res. 2020;177 doi: 10.1016/j.antiviral.2020.104759. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 10.Shi J, Wen Z, Zhong G. Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS-Coronavirus 2. Science. 2020;368:1016–1020. doi: 10.1126/science.abb7015. [DOI] [PMC free article] [PubMed] [Google Scholar]
Supplementary Material
mmc1.pdf (178.3KB, pdf)
Supplementary appendix
Associated Data
This section collects any data citations, data availability statements, or supplementary materials included in this article.
Supplementary Materials
mmc1.pdf (178.3KB, pdf)
Supplementary appendix