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. 2020 Oct 27;396(10264):1732–1733. doi: 10.1016/S0140-6736(20)32224-8

Who should be prioritised for COVID-19 vaccines?

Zaki Hassan-Smith a, Wasim Hanif a, Kamlesh Khunti b
PMCID: PMC7832613  PMID: 33125934

As effective vaccines and preventive medications become available for COVID-19, demand is likely to outstrip supply, so we need to develop a strategy to prioritise their use to ensure maximum public health and societal benefits. Interim advice from the Joint Committee on Vaccination and Immunisation1 suggests that people older than 65 years of age, those in shielding groups, and health-care workers should be prioritised for vaccination. The advice lacks detail, and it is essential that a plan is developed that takes the growing body of evidence on the effect of comorbidities, occupational, and socioeconomic factors on COVID-19 severity into account.

People living in areas with the highest levels of poverty and lowest levels of educational attainment have the highest rates of hospitalisation and are 1.9 times more likely to die from COVID-19.2 Physical crowding, homelessness, poor air quality, and smoke exposure are also associated with poorer outcomes.2 The disproportionate impact on minority ethnic groups is clear, and these communities are also more likely to be socioeconomically deprived, live in overcrowded conditions, and hold key worker or high exposure occupations.3

Planning for a culturally competent, transparent, and effective public health campaign is needed to ensure that vaccinations and preventive treatments are taken up in those most at risk of severe disease. Responsible messaging is needed to ensure adequate uptake and avoid stigmatisation and discrimination of disproportionately affected groups. This is critical when vaccines are being developed at an unprecedented rate and trust in safety and efficacy will be key. Previous work has suggested that enthusiasm for a vaccine during a pandemic is highest around the time that it is made available, so a well planned programme with outreach and education is needed to capitalise on this, and it is critical that a strategy is developed now.4

We propose a draft schema for prioritisation of vaccines and preventive medications based on our analysis of at-risk groups (appendix). This includes groups at risk of severe infection, including those with non-communicable diseases (eg, diabetes, hypertension, obesity, and cardiovascular disease) that should also be prioritised. High-risk occupational groups including those working in public facing roles, such as those in security and transport should also be included. Socioeconomic factors associated with adverse outcomes in COVID-19 should also be considered, and an effective strategy would include vaccination of those living in overcrowded conditions or in institutions such as care homes. Clinical prediction tools under development could be used to inform further risk stratification.5

Acknowledgments

KK is a member of the Independent Scientific Advisory Group for Emergencies subgroup on ethnicity and COVID-19, a trustee of the South Asian Health Foundation, and director of the Centre for BME Health. ZH-S and WH declare no competing interests.

Supplementary Material

Supplementary appendix
mmc1.pdf (69.4KB, pdf)

References

  • 1.Department of Health and Social Care Joint Committee on Vaccination and Immunisation: interim advice on priority groups for COVID-19 vaccination. Sept 25, 2020. https://www.gov.uk/government/publications/priority-groups-for-coronavirus-covid-19-vaccination-advice-from-the-jcvi-25-september-2020
  • 2.Barron E, Bakhai C, Kar P. Type 1 and type 2 diabetes and COVID-19 related mortality in England: a whole population study. Lancet Diabetes Endocrinol. 2020;8:813–822. doi: 10.1016/S2213-8587(20)30272-2. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 3.Khunti K, Routen A, Patel K. COVID-19 in Black, Asian and Minority Ethnic populations: an evidence review and recommendations from the South Asian Health Foundation. June 16, 2020. https://www.sahf.org.uk/covid19
  • 4.Schaffer DeRoo S, Pudalov NJ, Fu LY. Planning for a COVID-19 vaccination program. JAMA. 2020;323:2458–2459. doi: 10.1001/jama.2020.8711. [DOI] [PubMed] [Google Scholar]
  • 5.Hippisley-Cox J, Clift AK, Coupland CAC. Protocol for the development and evaluation of a tool for predicting risk of short-term adverse outcomes due to COVID-19 in the general UK population. medRxiv. 2020 doi: 10.1101/2020.06.28.20141986. published online June 29. (preprint) [DOI] [Google Scholar]

Associated Data

This section collects any data citations, data availability statements, or supplementary materials included in this article.

Supplementary Materials

Supplementary appendix
mmc1.pdf (69.4KB, pdf)

Articles from Lancet (London, England) are provided here courtesy of Elsevier

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