Table 4.
SwissTarget prediction of potential protein targets for NSC765690 and NSC765599.
| Gene Name | Common Name | Uniprot ID | ChEMBL ID | Target Class |
|---|---|---|---|---|
| NSC765690 Targets | ||||
| CDK9/cyclin T1 | CDK9, CCNT1 | P50750 O60563 | CHEMBL2111389 | Other cytosolic protein |
| Cyclin-dependent kinase 1 | CDK1 | P06493 | CHEMBL308 | Kinase |
| Cyclin-dependent kinase 1/cyclin B | CCNB3 CDK1 CCNB1 CCNB2 | Q8WWL7 P06493 P14635 O95067 | CHEMBL2094127 | Other cytosolic protein |
| Cyclin-dependent kinase 2 | CDK2 | P24941 | CHEMBL301 | Kinase |
| Cyclin-dependent kinase 4/cyclin D1 | CCND1 CDK4 | P24385 P11802 | CHEMBL1907601 | Kinase |
| Epidermal growth factor receptor erbB1 | EGFR | P00533 | CHEMBL203 | Kinase |
| Signal transducer and activator of transcription 3 | STAT3 | P40763 | CHEMBL4026 | Transcription factor |
| Fibroblast growth factor receptor 1 | FGFR1 | P11362 | CHEMBL3650 | Kinase |
| Insulin receptor | INSR | P06213 | CHEMBL1981 | Kinase |
| MAP kinase ERK2 | MAPK1 | P28482 | CHEMBL4040 | Kinase |
| PI3-kinase p110-gamma subunit | PIK3CG | P48736 | CHEMBL3267 | Enzyme |
| Platelet-derived growth factor receptor | PDGFRA PDGFRB | P16234 P09619 | CHEMBL2095189 | Kinase |
| Rho-associated protein kinase 1 | ROCK1 | Q13464 | CHEMBL3231 | Kinase |
| Serine/threonine-protein kinase 11/16/Chk1/MST2 | STK11/3/16/CHEK1 | Q15831 | CHEMBL5606 | Kinase |
| Tyrosine-protein kinase ABL/ITK/JAK1/JAK2 | ABL1 | P00519 | CHEMBL1862 | Kinase |
| NSC765599 Targets | ||||
| Cyclin-dependent kinase 5/CDK5 activator 1 | CDK5R1 CDK5 | Q15078 Q00535 | CHEMBL1907600 | Kinase |
| Epidermal growth factor receptor erbB1 | EGFR | P00533 | CHEMBL203 | Kinase |
| Cyclin-dependent kinase 2 | CDK2 | P24941 | CHEMBL301 | Kinase |
| Cyclin-dependent kinase 4/cyclin D1 | CCND1, CDK4 | P24385, P11802 | CHEMBL1907601 | Kinase |
| Hepatocyte growth factor receptor | MET | P08581 | CHEMBL3717 | Kinase |
| Inhibitor of NF-kappa-B kinase (IKK) | CHUK | O15111 | CHEMBL3476 | Kinase |
| Insulin-like growth factor I receptor | IGF1R | P08069 | CHEMBL1957 | Kinase |
| MAP kinase p38 alpha | MAPK14 | Q16539 | CHEMBL260 | Kinase |
| CDK6/cyclin D1 | CCND1, CDK6 | P24385, Q00534 | CHEMBL2111455 | Kinase |
| PI3-kinase p110-alpha/p85-alpha | PIK3CA, PIK3R1 | P42336, P27986 | CHEMBL2111367 | Enzyme |
| Receptor protein-tyrosine kinase erbB-2 | ERBB2 | P04626 | CHEMBL1824 | Kinase |
| Receptor protein-tyrosine kinase erbB-4 | ERBB4 | Q15303 | CHEMBL3009 | Kinase |
| Rho-associated protein kinase 1 | ROCK1/2 | Q13464 | CHEMBL3231 | Kinase |
| Signal transducer and activator of transcription 3 | STAT3 | P40763 | CHEMBL4026 | Transcription factor |
| Serine/threonine-protein kinase RIPK2 | RIPK2 | O43353 | CHEMBL5014 | Kinase |
| Tankyrase−1/2 | TNKS, TNKS2 | O95271, Q9H2K2 | CHEMBL6164, 6154 | Enzyme |
| Tyrosine-protein kinase JAK1 | JAK1 | P23458 | CHEMBL2835 | Kinase |
| Tyrosine-protein kinase SRC | SRC | P12931 | CHEMBL267 | Kinase |
| Vascular endothelial growth factor receptor 1/2 | FLT1, KDR | P17948, P35968 | CHEMBL1868, 279 | Kinase |
Targets were predicted using Swiss Target Prediction, which operates on the principle of ‘similarity’.