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Specificity of LIG1 variant R771W for the ligation of repair intermediates with 3’-pre-inserted mismatches opposite templates A and T. (A, B) The graphs show the time-dependent changes in the ligation (blue) and ligation failure (red) products for 3’-pre-inserted mismatches opposite templates A (A) and T (B). The data are presented as the averages from three independent experiments ± SDs. The gel images are presented in Supplementary Figure 9.
