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. 2020 Sep 11;35(5):391–404. doi: 10.1093/mutage/geaa023

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Figure 7. — Structure model of LIG1 with R641L identified in LIG1 deficiency syndrome. (A) Ribbon diagram showing LIG1 encircling a nicked DNA duplex (orange). Arg641 (magenta) shown as sticks is located in Loop A (green). (B) Arg641 (R641) interacts with K597, D600 and V653, and (C) the replacement of Arg641 with Leu (L641) disrupts the interaction and destabilises Loop A (shown in dotted green line). All residues are shown as sticks. Positive and negative potentials are shown in blue and red, respectively.