Fig. 4.

Filtering structural connectomes based on clinical improvement. (A) Active contact locations from 50 patients (four cohorts) that underwent DBS surgery for OCD to multiple different neuranatomical targets are shown as small spheres. The color of each sphere refers to the cohort (Li et al., 2020). Fiber tracts from a normative structural connectome were identified that traversed the stimulation site more frequently in patients with good clinical response (red) versus poor clinical response (blue). (B) The same method was applied to data from 51 patients that underwent STN-DBS for PD and identified the premotor hyperdirect pathway (red fibers) as being associated with better clinical response (Treu et al., 2020).