Fig. 3.

Inhibition of BMP signaling improves EAE clinical outcomes. (a) EAE mice were randomized when the first clinical symptoms appeared (clinical score ≥ 1) and treated daily with 3 mg/kg DM, 5 mg/kg DMH1, or DMSO (vehicle). (b) EAE clinical outcomes improved in mice treated with the BMP signaling inhibitors, and the area under the curve tended to decrease in DMH1-treated mice. Data compile two independent experiments and are presented as the mean ± standard error of the mean (SEM). The statistical analysis was performed with mixed models to account for clustering by experiment. AUC = area under the curve; DM = dorsomorphin; DMH1 = dorsomorphin homologue 1. The arrow indicates the start of treatment