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. Author manuscript; available in PMC: 2022 Feb 15.
Published in final edited form as: Neuropharmacology. 2020 Nov 18;184:108408. doi: 10.1016/j.neuropharm.2020.108408

Figure 6. Nociceptor hyperexcitability induced by 5-HT does not require HCN activity.

Figure 6.

Rat DRG neurons were treated 100 μM ZD7288 before and during exposure to 100 nM 5-HT. (A) Effect of ZD7288 on the incidence of OA during exposure to 5-HT. The occurrence of OA was measured during ≥60-s recordings at RMP then during 30-s depolarization to −45 mV. (B-E) Effects of ZD7288 on the frequency of medium- (3–5 mV) and large-amplitude (>5 mV) DSFs during 30-s depolarization to −45 mV (B), frequency of AP firing during 30-s recordings at −45 mV (C), AP voltage threshold (D), and rheobase (E) in the presence of 5-HT. Mean ± SEM.