Innate immune responses in RNA viral infection

Qian Xu; Yuting Tang; Gang Huang

doi:10.1007/s11684-020-0776-7

. 2020 Dec 1;15(3):333–346. doi: 10.1007/s11684-020-0776-7

Innate immune responses in RNA viral infection

Qian Xu ^1,², Yuting Tang ¹, Gang Huang ^1,^✉

PMCID: PMC7862985 PMID: 33263837

Abstract

RNA viruses cause a multitude of human diseases, including several pandemic events in the past century. Upon viral invasion, the innate immune system responds rapidly and plays a key role in activating the adaptive immune system. In the innate immune system, the interactions between pathogen-associated molecular patterns and host pattern recognition receptors activate multiple signaling pathways in immune cells and induce the production of pro-inflammatory cytokines and interferons to elicit antiviral responses. Macrophages, dendritic cells, and natural killer cells are the principal innate immune components that exert antiviral activities. In this review, the current understanding of innate immunity contributing to the restriction of RNA viral infections was briefly summarized. Besides the main role of immune cells in combating viral infection, the intercellular transfer of pathogen and host-derived materials and their epigenetic and metabolic interactions associated with innate immunity was discussed. This knowledge provides an enhanced understanding of the innate immune response to RNA viral infections in general and aids in the preparation for the existing and next emerging viral infections.

Keywords: innate immune, viral infection, intercellular signaling, metabolic changes, epigenetic changes

Footnotes

Compliance with ethics guidelines

Qian Xu, Yuting Tang, and Gang Huang declare no conflict of interest. This manuscript is a review article. It does not involve a research protocol requiring approval by relevant institutional review board or ethics committee.

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Innate immune responses in RNA viral infection

Qian Xu

Yuting Tang

Gang Huang

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Innate immune responses in RNA viral infection

Qian Xu

Yuting Tang

Gang Huang

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