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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Chemosphere. 2020 Jan 3;247:125825. doi: 10.1016/j.chemosphere.2020.125825

Fig. 6. Schematic summary depicting fluoride-mediated HAT activation and acetylation of p53 to promote fluoride toxicity in LS8 cells.

Fig. 6.

NaF activated HATs increasing Acetyl-CBP/P300 (Ac-CBP/P300), PCAF and phosho-Tip60 (p-Tip60). NaF increased p53-CBP binding and p53-PCAF binding to increase acetyl-p53 (Ac-p53). Anacradic Acid; AA (CBP/P300 and PCAF inhibitor) or MG149 (Tip60 inhibitor) mitigated fluoride toxicity including cell growth inhibition and apoptosis in LS8 cells.