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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Science. 2020 Nov 26;371(6524):eabd1673. doi: 10.1126/science.abd1673

Fig. 7. Inactivation.

Fig. 7.

(A,B) Side-by-side comparison of selected elements in the inhibited complex (top) and in the moribund complex (bottom), highlighting movement of the β’ clamp helices (CH, magenta) and nucleic acid-guiding loops (lid/rudder/switch 2, magenta) (A), as well as repositioning of the hybrid and displacement of the RNA 3’-end from the active site (arrow) (B). (C) Pause-resistant βV550A substitution decreases ρ termination. Reactions were run on the same gel, and a dashed line indicates the splice position. (D) Effects of NTP concentration at λ tR1.