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. 2021 Jan 21;26(3):553. doi: 10.3390/molecules26030553

Table 1.

In vitro inhibition of vascular endothelial growth factor receptor 2 (VEGFR-2) by the quinolin-2-one analogues (1–10) [41].

Compound Y R1 R2 VEGFR-2 (IC50 μM) PDGFRβ (IC50 μM)
1 OH H H 0.24 0.020
2 NH2 H H 0.058 0.010
3 NHMe H H 0.22 0.030
4 graphic file with name molecules-26-00553-i001.jpg H H 0.17 0.0002
5 H graphic file with name molecules-26-00553-i002.jpg H 0.017 0.0003
6 NH2 graphic file with name molecules-26-00553-i003.jpg H 0.005 0.0001
7 NH2 H Me 0.22 0.030
8 NH2 H graphic file with name molecules-26-00553-i004.jpg 0.057 0.005
9 NH2 H graphic file with name molecules-26-00553-i005.jpg 0.027 0.002
10 NH2 H graphic file with name molecules-26-00553-i006.jpg 0.026 0.0009