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. 2021 Jan 21;26(3):553. doi: 10.3390/molecules26030553

Table 3.

In vitro inhibition of hypoxia inducible factor 1 (HIF-1) transcriptional activity in cell-based HRE reporter assay by the benzenesulfonamide analogues (13–18) [72].

graphic file with name molecules-26-00553-i008.jpg
Compound R1 R2 LN229-HRE-Lux (IC50 μM)
13 graphic file with name molecules-26-00553-i009.jpg graphic file with name molecules-26-00553-i010.jpg 0.6 μM
14 graphic file with name molecules-26-00553-i011.jpg graphic file with name molecules-26-00553-i012.jpg 0.6 μM
15 graphic file with name molecules-26-00553-i013.jpg graphic file with name molecules-26-00553-i014.jpg 1.3 μM
16 graphic file with name molecules-26-00553-i015.jpg graphic file with name molecules-26-00553-i016.jpg 3.3 μM
17 graphic file with name molecules-26-00553-i017.jpg graphic file with name molecules-26-00553-i018.jpg >25 μM
18 graphic file with name molecules-26-00553-i019.jpg graphic file with name molecules-26-00553-i020.jpg 0.5 μM