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The effect of compounds 7a and 7b on transcriptional activity of TP53 for SNB-19 (A) and C-32 (B) cells. Cells were exposed to compound 7a and 7b for 24 h at a concentration equal to half of IC50 determined for SNB-19 (0.3 and 0.25 µg/mL, respectively) and for C-32 (0.7and 0.25 µg/mL, respectively). For the reference compound, cisplatin, the appropriate concentrations were 0.8 µg/mL (SNB-19 line) and 0.6 µg/mL (C32 line). * p < 0.05 compared with the untreated control.
