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. 2020 Aug 7;35(4):1023–1036. doi: 10.1038/s41375-020-1003-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — NSG mice were tail-vein inoculated with patient-derived AML cells (1 × 10⁶ cells/mouse) and on Day 9 after inoculation randomized to the treatments as shown (n = 7/group). Mice were euthanized if there were signs of distress. a Experiment schema; b Time-to-distress and euthanasia. c Bone marrow human (hCD45) and murine (mCd45) myelopoiesis content. Femoral bones flushed after euthanasia. Measured by flow-cytometry. Median ± IQR. d Spleen weights at time-of-distress/euthanasia. Median ± IQR. e Spleens at the time-of-distress/euthansia.