Extended Data Fig. 5. ERRγ is required for WNT4-driven metabolic maturation.

a-b, Postnatal islets (day P11–14) from WT and β cell specific ERRγKO mice were cultured with or without rhWNT4 (100ng/ml) for >5 days. Relative gene expression measured by qPCR (a), and insulin secretion in response to 3mM and 20mM glucose (b). n=3. Error bars represent ± SEM.*p<0.05, **p<0.01, ***p<0.001, one-tailed, student’s paired t test. Data representative of 2 independent experiments (a, b).