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. 2021 Jan 11;162(4):bqab007. doi: 10.1210/endocr/bqab007

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© The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 1. — Effect of hepatic Argonaute 2 (Ago2) deficiency on glucose metabolism of diabetic obese mice. A, Body weight of liver-specific Ago2-deficiency (L-Ago2) wild-type (WT)-ob/ob (n = 16), and L-Ago2 knockout (KO)-ob/ob (n = 13) mice on normal chow (CD) from age 5 to 12 weeks. B, Food intake normalized by body weight per day of L-Ago2 WT-ob/ob (n = 21), and L-Ago2 KO-ob/ob (n = 24) mice at age 11 weeks. C, Blood glucose levels after 6 hours of fasting of L-Ago2 WT-ob/ob (n = 20) and L-Ago2 KO-ob/ob (n = 16) at age 13 weeks. D, Glucose tolerance test (GTT) and its area under the curve (AUC) analysis in L-Ago2 WT-ob/ob (n = 18) and L-Ago2 KO-ob/ob (n = 18) mice at age 7 weeks. E, Serum insulin levels after 6 hours of fasting of L-Ago2 WT-Lean (n = 3), L-Ago2 WT-ob/ob (n = 4), L-Ago2 KO-Lean (n = 3), and L-Ago2 KO-ob/ob (n = 7) mice at age 13 weeks. F, Insulin tolerance test (ITT) and its AUC analysis in L-Ago2 WT-ob/ob (n = 18) and L-Ago2 KO-ob/ob (n = 18) mice at age 9 weeks. G, Messenger RNA (mRNA) expression levels of de novo lipogenesis and gluconeogenesis in livers of L-Ago2 WT-Lean (n = 5), L-Ago2 WT-ob/ob (n = 10), L-Ago2 KO-Lean (n = 5), and L-Ago2 KO-ob/ob (n = 4) mice after overnight fasting at age 13 weeks. H, Metabolic disease–associated microRNAs (MD-miRNAs) and I, their target mRNA expression levels in livers of L-Ago2 WT-Lean (n = 5), L-Ago2 WT-ob/ob (n = 10), L-Ago2 KO-Lean (n = 5), and L-Ago2 KO-ob/ob (n = 4) mice after overnight fasting at age 13 weeks. Data are shown as mean ± SEM of group size (n). Statistical analyses were performed by unpaired 2-tailed t test for C, D, and F or by 2-way analysis of variance followed by Tukey post hoc test for E, G, H, and I. *P less than or equal to .05, **P less than or equal to .01, ***P less than or equal to .001.