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PLOS One logoLink to PLOS One
. 2021 Feb 10;16(2):e0246784. doi: 10.1371/journal.pone.0246784

Psychological distress among health service providers during COVID-19 pandemic in Nepal

Khagendra Kafle 1, Dhan Bahadur Shrestha 2,*, Abinash Baniya 3, Sandesh Lamichhane 3, Manoj Shahi 3, Bipana Gurung 3, Partiksha Tandan 3, Amrita Ghimire 4, Pravash Budhathoki 5
Editor: Simone Savastano6
PMCID: PMC7875377  PMID: 33566863

Abstract

Background

COVID-19 pandemic has provoked a wide variety of psychological problems such as anxiety, depression, and panic disorders, especially among health service providers. Due to a greater risk of exposure to the virus, increased working hours, and fear of infecting their families, health service providers are more vulnerable to emotional distress than the general population during this pandemic. This online survey attempts to assess the psychological impact of COVID-19 and its associated variables among healthcare workers in Nepal.

Materials and methods

For data collection purposes, Covid-19 Peritraumatic Distress Index (CPDI) Questionnaire, was used whose content validity was verified by Shanghai mental health center. Data for the survey were collected from 11 to 24 October 2020 which was extracted to Microsoft Excel-13 and analyzed.

Results

A total of 254 health care workers from different provinces of the country participated in this study with a mean age of 26.01(± 4.46) years. A majority 46.9% (n = 119) of the participants were not distressed (score ≤28) while 46.5% (n = 118) were mild to moderately distressed (score >28 to ≤51) and 6.7% (n = 17) were severely distressed (score ≥52) due to the current COVID-19 pandemic. Female participants (p = 0.004) and participants who were doctors by profession (p = 0.001) experienced significantly more distress.

Conclusions

COVID-19 pandemic has heightened the psychological distress amongst health care service providers. The findings from the present study may highlight the need for constructing and implementing appropriate plans and policies by relevant stakeholders that will help to mitigate the distress among health service providers in the current pandemic so that we can have an efficient frontline health workforce to tackle this worse situation.

Introduction

The Coronavirus disease 2019 (COVID-19), as named by the World Health Organization (WHO), first emerged as a cluster of unknown pneumonia cases in Wuhan in late December 2019 [1, 2]. This outbreak had spread substantially throughout the world for which it was declared as a Public Health Emergency of International Concern (PHEIC) on 30th January 2020 and as a pandemic by the World Health Organization (WHO) on March 11, 2020 [3, 4]. As of October 29, 2020, COVID-19 has accounted for 43,766,712 confirmed cases and 1,163,459 deaths across 219 territories [5]. Nepal registered its first case of COVID-19 on January 23, 2020. Despite adopting operative measures like nationwide lockdown, social distancing, and travel restrictions, the COVID-19 cases are in increasing trend in Nepal. Till October 29, 2020, there have been 164,718 confirmed cases of COVID-19, of which 124,862 (75.8%) had recovered and 904 (0.6%) deaths have been recorded [6].

The current COVID-19 pandemic has not only caused significant threats to people’s physical health and lives but has also provoked a wide variety of psychological problems such as anxiety, depression, and panic disorders [7]. During acute health crises like the current COVID-19 pandemic, healthcare systems and facilities are under extreme pressure for providing appropriate diagnostic and treatment services due to which the working life of health service providers in affected regions has become more stressful than normal [8]. Health service providers who are working as front liners in the current pandemic are more vulnerable to emotional distress than the general population as they have a greater risk of exposure to the virus, increased workload/working hours, fear of infecting their family and friends, lack of experience in managing the disease, perceived stigma, significant lifestyle changes, social discrimination and lack of personal protective equipment (PPE) [912]. The increased infection rate among healthcare workers is another important cause of such psychological impact [13].

During this crucial period, a more comprehensive understanding of the psychological burden among different groups of health service providers is essential so that appropriate psychological support could be provided and also strengthening mental healthcare could be done [14]. This cross-sectional study attempts to assess the psychological impact of COVID-19 and its associated variables among different healthcare workers in Nepal.

Materials and methods

This study is a nationwide, web-based cross-sectional survey of psychological distress among health service providers during the COVID-19 pandemic in Nepal. Data for the survey were collected from 11 to 24 October 2020. The survey was filled by health professionals working in various institutes like hospitals, primary health centers, nursing homes, pharmacies, health posts and sub-health posts. Hospitals were teaching hospitals, district hospitals, regional hospitals, zonal hospitals and private hospitals. Medical professionals ranged from doctors, nurses, pharmacists, dentists, auxiliary health workers working in different departments ranging from intensive care units, wards, emergency departments, pharmacy shops, etc. For data collection purposes COVID-19 Peritraumatic Distress Index (CPDI) Questionnaire was used whose content validity was verified by Shanghai Mental Health Center [7]. As specified in the International Classification of Diseases, 11th Revision, apart from demographic data (age, gender, religion, education, occupation, workload, availability of safety measures, nationality, ethnicity, and residence) the CPDI questionnaire includes relevant diagnostic guidelines for specific phobias and stress disorders and further inquiries about the frequency of anxiety, depression, cognitive change, avoidance, and compulsive behavior, physical symptoms and loss of social functioning in the past week, ranging from 0 to 96. Informed consent was taken from participants at the beginning of the questionnaire. For the survey, data were collected through an online Google form. Social media network was used to publish structured Google form with CPDI questions and forms were disseminated via email, messenger, Facebook group, Viber, etc. to the health care workers requesting them to participate in the survey and also to share the survey form to a wider audience. The eligible participants for the survey were physicians (including residents and fellows), advanced practice providers or registered nurses, and other service providers working at medical centers. Medical students were excluded from this survey as most of them usually do not enter the stage of clinical practice.

Sample size

The minimum sample size required was 156. Sample size was determined using the formula:

N=[(z)2*p(1p)]/e2;

where ‘z’ is 1.96 at 95% confidence interval, ‘e’ is margin of error at 5% and ‘p’ is prevalence rate of 11.5% from a recent study done in Nepal [15]. Adding 10% of the minimum sample as non- respondent, the desired sample size becomes 172.

Exposure variables

Socioeconomic and demographic variables such as age (<30, 30–45, >45), Gender (male and female), Religion (non- Hinduism and Hinduism), Education (Diploma, bachelors or masters), employment (Doctor, nurse or other health care worker), Marital status (married, unmarried, widowed or divorced), Nationality (Nepali, non-Nepali), Ethnicity (Brahmin and Chhetri, Others), Residence (Province 1,2,3,4,5,6,7) were included in the survey questionnaire.

Outcome variables

This study used the CPDI scale questionnaire with an additional socio-demographic questionnaire and the internal consistency of 24 CPDI variables was assessed by using Cronbach’s α. Its internal reliability was found to be 0.905 indicating high internal consistency of the scale.

The 5- point Likert scoring system with scales ranging from never-0, occasionally-1, sometimes-2, often-3, always-4 was used. The total score thus calculated is classified as:- score between 0–28 is normal, 28 and 51 mild or moderate distress and ≥52 severe distress.

Statistical analysis

Data of the Survey was exported into Microsoft Excel-13. The data then imported, cleaned, categorized as appropriate, and analyzed using SPSS (Statistical Package for Social Science) version-22. For all the variables, a univariate analysis was performed to assess the distribution of each variable in frequency and the percentage to summarize categorical variables. Odds ratios of relevant predicting variables were estimated using logistic regression analysis which gives the relation between a set of predictor set X (exposure variable) and a dichotomous response variable Y(outcome variable). For ease, we specify the response to be Y = 0 or 1, with Y = 1 designating the occurrence of the event of interest. The outcome variable is No distress = 0 and distress = 1. The exposure variables were categorical.

Research ethics

Before the survey, informed consent was obtained from all the respondents. The study was conducted following the protocol, approved by the ethics committee of Chitwan Medical College Teaching Hospital (letter-number- CMC-IRC/077/078-041).

Results

A total of 257 health care workers participated in this survey. Three forms were incomplete so excluded and data from 254 participants were included in the analysis. The socioeconomic and demographic profile of responders is outlined in Table 1. In this study, the majority of respondents (85.4%) were less than 30 years old and the mean age of participants was 26.01(±4.46) years. The male to female ratio is 1.01 with 50.04% male participants. The majority of participants were Hindu by religion (90.2%), Doctor by occupation (42.5%), completed bachelor’s level or master’s level (89.8%), and working in non-government hospitals (72%). Though most of the respondents work more than 4 days a week (71.1%) and more than or equal to 40 hrs per week (83.5%), almost two-thirds (63.8%) of these health care workers didn’t receive any extra allowance. Approximately two-thirds of participants are residing in Bagmati province (61.8%).

Table 1. Socio-demographic profile of the health care workers (N = 254).

Socio-demographic variables Frequency Percent
Age <30 217 85.4
30–45 36 14.2
>45 1 .4
Mean ± SD 26.01±4.46
Sex Women 126 49.6
Men 128 50.4
Religion Non-Hinduism 25 9.8
Hinduism 229 90.2
Education Diploma 26 10.2
Bachelor or master 228 89.8
Employment Doctor 108 42.5
Nurse 61 24.0
Other HCW 85 33.5
Current Job Government 71 28.0
Non-Government 183 72.0
Institute category Hospitals or higher center 199 78.3
PHC, Health post, or others 55 21.7
Work in weeks per month Less than 4 weeks per month 48 18.9
4 weeks per month 206 81.1
Duty HRS per week Less than 40 hrs 39 15.4
More than or equal 40 hrs 212 83.5
Missing 3 1.2
Use of PPE Complete set 42 16.5
Incomplete 209 82.3
Missing 3 1.2
Extra allowance May be or Yes 89 35.0
No 162 63.8
Missing 3 1.2
Marital status Married 38 15.0
Unmarried 214 84.3
Widowed or divorced 2 .8
Nationality Non-Nepali 3 1.2
Nepali 251 98.8
Ethnicity Brahmin and Chettri 162 63.8
Others 92 36.2
Residence Province 1 (Biratnagar as territorial capital) 9 3.5
Province 2 (Janakpur as territorial capital) 11 4.3
Province 3 (Bagmati) 157 61.8
Province 4 (Gandaki) 28 11.0
Province 5 (Butwal as territorial capital) 34 13.4
Province 6 (Karnali) 12 4.7
Province 7 (Sudurpaschim) 3 1.2

NB: Nepal is yet to name all the provinces under the mandate of the new constitution and federal People’s Republic

Table 2 depicts the prevalence of every psychological component of the CPDI scale. More than two-third (n = 222, 87.4%) used to feel more nervous and anxious. Similarly, 74.8% of respondents (n = 190) felt insecure and bought a lot of masks, medications, sanitizers, gloves, and/or other home supplies. About half (n = 120, 47.2%) of the participants always felt sympathetic to COVID-19 patients and their families. Only approximately one third (n = 86, 33.9%) of the respondents believed the COVID-19 information from all sources without any validation. Approximately two-thirds (n = 170, 66.9%) didn’t believe in negative news about COVID-19 and was not skeptical about the good news.

Table 2. Presence of symptoms COVID-19 peri-traumatic distress (CPDI).

Questions Never Occasionally Sometimes Often Always
n(%) n(%) n(%) n(%) n(%)
Question 1: Compared to usual, I feel more nervous and anxious. 32(12.6) 45(17.7) 111(43.7) 50(19.7) 16(6.3)
Question 2: I feel insecure and bought a lot of masks, medications, sanitizers, gloves, and/or other home supplies. 64(25.2) 50(19.7) 68(26.8) 40(15.7) 32(12.6)
Question 3: I can’t stop myself from imagining myself or my family being infected and feel terrified and anxious about it. 39(15.4) 54(21.3) 66(26.0) 55(21.7) 40(15.7)
Question 4: I feel helpless no matter what I do. 100(39.4) 57(22.4) 62(24.4) 23(9.1) 12(4.7)
Question 5: I feel sympathetic to COVID-19 patients and their families. 7(2.8) 21(8.3) 39(15.4) 67(26.4) 120(47.2)
Question 6: I feel helpless and angry about people around me, governors, and media. 41(16.1) 41(16.1) 75(29.5) 51(20.1) 46(18.1)
Question 7: I am losing faith in the people around me. 91(35.8) 49(19.3) 68(26.8) 32(12.6) 14(5.5)
Question 8: I collect information about COVID-19 all day. Even if it’s not necessary, I can’t stop myself. 73(28.7) 63(24.8) 58(22.8) 30(11.8) 30(11.8)
Question 9: I will believe the COVID-19 information from all sources without any evaluation. 168(66.1) 36(14.2) 30(11.8) 12(4.7) 8(3.1)
Question 10: I would rather believe in negative news about COVID-19 and be skeptical about the good news. 170(66.9) 33(13.0) 31(12.2) 7(2.8) 13(5.1)
Question 11: I am constantly sharing news about COVID-19 (mostly negative news). 172(66.7) 46(18.1) 28(11.0) 5(2.0) 3(1.2)
Question 12: I avoid watching COVID-19 news since I am too scared to do so. 140(55.1) 45(17.7) 52(20.5) 12(4.7) 5(2.0)
Question 13: I am more irritable and have frequent conflicts with my family. 140(55.1) 53(20.9) 42(16.5) 16(6.3) 3(1.2)
Question 14: I feel tired and sometimes even exhausted. 32(12.6) 64(25.2) 94(37.0) 49(19.3) 15(5.9)
Question 15: When feelings anxious, my reactions are becoming sluggish. 64(25.2) 75(29.5) 61(24.0) 43(16.9) 11(4.3)
Question 16: I find it hard to concentrate. 58(22.8) 73(28.7) 82(32.3) 31(12.2) 10(3.9)
Question 17: I find it hard to make any decisions. 71(28.0) 80(31.5) 70(27.6) 22(8.7) 11(4.3)
Question 18: During this COVID-19 period, I often feel dizzy or have back pain and chest distress. 119(46.9) 57(22.4) 55(21.7) 17(6.7) 6(2.4)
Question 19: During this COVID-19 period, I often feel stomach pain, bloating, and other stomach discomforts. 129(50.8) 57(22.4) 56(22.0) 10(3.9) 2(0.8)
Question 20: I feel uncomfortable when communicating with others. 106(41.7) 61(24.0) 56(22.0) 23(9.1) 8(3.1)
Question 21: Recently, I rarely talk to my family. 145(57.1) 44(17.3) 41(16.1) 15(5.9) 9(3.5)
Question 22: I have frequent awakening at night due to my dream about myself or my family being infected by COVID-19. 184(72.4) 40(15.7) 19(7.5) 5(2.0) 6(2.4)
Question 23: I have changes in my eating habits 98(38.6) 53(20.9) 46(18.1) 36(14.2) 21(8.3)
Question 24: I have constipation or frequent urination. 173(68.1) 33(13.0) 28(11.0) 17(6.7) 3(1.2)

114 of the respondents (44.9%) would avoid watching COVID-19 news and a similar percentage of the respondents would be irritable and had a conflict with their family. More than half (n = 135, 53.1%) of the participants would feel dizzy or have back pain and chest distress and 49.2% of them would feel stomach pain, bloating, and other stomach discomforts. In addition to this, 58.3% would feel uncomfortable when communicating with others, 61.4% had changes in their eating habits and 31.9% had constipation or frequent urination.

Table 3 demonstrates the distribution of severity of psychological distress by socioeconomic and demographic characteristics of Nepal. The frequency of mild to moderate distress among age groups <30 years, 30–45 years, and >45 years old were 104, 13, and 1 respectively whereas 14 severely distressed health service providers were below <30 years old. Female participants were having more distress (n = 80) compared to male participants (n = 55) which were statistically significant (p = 0.004). Additionally, participants who were doctors by profession experienced significantly more distress (n = 50, p = 0.001). Socioeconomic and demographic characteristics of participants like religion, education level, working hours, marital status, ethnicity, province of residence, and extra allowance were not significantly associated with distress level.

Table 3. Prevalence of CPDI by socioeconomic and demographic characteristics among HCWs in Nepal.

Socio-demographic Variables No distress (n) Mild- moderate distress (n) Severe distress (n) p-value
Age <30 99 104 14 .575
30–45 20 13 3
>45 0 1 0
Sex Women 46 69 11 .004
Men 73 49 6
Religion Non-Hinduism 14 9 2 .544
Hinduism 105 109 15
Education Diploma 8 14 4 .074
Bachelor or master 111 104 13
Employment Doctor 58 46 4 .001
Nurse 16 36 9
Other HCW 45 36 4
Current Job Government 40 26 5 .138
Non-Government 79 92 12
Institute category Hospitals or higher center 89 97 13 .376
PHC, Health post, or others 30 21 4
Work in weeks per month Less than 4 weeks per month 19 27 2 .293
4 weeks per month 100 91 15
Duty HRS per week Less than 40 hrs 20 18 1 .490
More than or equal 40 hrs 97 99 16
Use of PPE Complete 18 24 0 .092
Incomplete 99 93 17
Extra allowance May be or Yes 45 41 3 .243
No 72 76 14
Marital status Married 22 14 2 .358
Unmarried 97 102 15
Widowed or divorced 0 2 0
Nationality Non-Nepali 2 1 0 .752
Nepali 117 117 17
Ethnicity Others 36 48 8 .156
Brahmin and Chhetri 83 70 9
Residence Province 1 (Biratnagar as territorial capital) 7 2 0 .232
Province 2 (Janakpur as territorial capital) 4 5 2
Province 3 (Bagmati) 68 79 10
Province 4 (Gandaki) 18 10 0
Province 5 (Butwal as territorial capital) 15 16 3
Province 6 (Karnali) 6 5 1
Province 7 (Sudurpaschim) 1 1 1

46.9% (n = 119) of the participants were not distressed while 46.5% (n = 118) were mild to moderate distressed and 6.7% (n = 17) were severely distressed due to COVID-19 pandemic (Fig 1).

Fig 1. Prevalence of psychological distress among HCWs in Nepal.

Fig 1

Binary logistic regression analysis taking socio-demographic determinants of distress didn’t show any significant association (Table 1 in S1 File).

Discussion

A total of 254 health care workers from different provinces of the country participated in this study with a mean age of 26.01(± 4.46) years. The male to female ratio is 1.01 with 50.4% male participants. The findings of this study are consistent with another study conducted in Nepal, where 54.2% were male with a mean age of 27.8 years [16]. Though the survey was completed by a similar number of male and female participants with doctors and nurses being the largest two groups, the prevalence of distress among females was found to be higher which is comparable with the outcome of a study conducted in Nepal [15] and Saudi Arabia [17]. Concern for family members and lack of proper knowledge regarding epidemics and public health emergencies may be the major cause for stress among females pointing towards the critical role of family and community support for mental health [18]. Higher workload and greater risk of direct exposure to COVID-19 patients have increased the vulnerability of females especially nurses for mental health [19].

Though it was a nationwide survey, we have a maximum number of participants from Bagmati province. The reason could be, this province includes the national capital city Kathmandu and other major cities where comparatively a greater number of health professionals are supposed to be working. Most of the participants were educated till bachelor or higher level. The majority were working in non-government settings. This is expected as only a small proportion of all health forces are working under government and most of them are employed with non-government organizations [20].

A survey in China demonstrated that age, occupation, mass media report, and perception towards outbreak and public health emergencies bring significant variation in psychological distress among different individuals [21]. Many studies have shown that the risk of psychological problems is relatively more among health care workers than non-health workers as they are being exposed to patients with COVID-19 [22]. Psychological distress was found to be higher in doctors than in other HCWs in this study (p = 0.001). Doctors experience higher levels of mental stress during normal circumstances and health emergencies like COVID-19 exert additional pressure on doctors and the whole health care system [23].

The prevalence of mild distress was reported to be lower among health workers from China (36.5%) [24] and in Saudi Arabia (33.7%) [17] as compared to the findings of our study. In addition to this, the prevalence of mild-moderate distress (46.5%) and severe distress (6.7%) in this study was found to be higher as compared to a recent study conducted in Nepal among the general population, which showed that 11% of the participants had mild psychological distress while only 0.5% of them reported with severe distress [15]. This might be attributed greatly to the fact that healthcare workers are facing tremendous pressure from COVID-19 including a high risk of exposure to infection, inadequate protection due to shortage of healthcare resources, long duty hours, perceived stigma, lack of family contact, and the possibility of family illness in addition to early and evolving nature of pandemic when the study was conducted [11, 25]. These factors can contribute to psychological problems in a substantial proportion of healthcare workers including depression, anxiety, insomnia, distress, obsessive-compulsive symptoms, and somatization symptoms [24, 26]. Notably, depression and posttraumatic stress symptoms might remain even after crises like the current pandemic are over [27, 28] and might as well surpass the consequences of the current pandemic itself [14].

The shortage of PPE wasn’t statistically significant in our study, which might be due to adopting the participants with the current situation. However, several studies have reported this as a considerable source of distress among healthcare workers [25, 29, 30] and have specified the need to equip these frontline workers with adequate resources which can strengthen their overall work performance with better psychological outcomes [25, 31]. Lack of protective measures can create a sense of insecurity and thus imposes the healthcare workers to higher exposure to infections. Thus, these findings draw attention to the government of Nepal for providing adequate protective measures to lessen the escalating mental health burden among healthcare workers [30].

There is generally a higher risk of suicide among healthcare workers as compared to the general population [32] and COVID-19 has heightened this burden of suicide among healthcare workers [33]. There is no study relating to suicide rates in Nepal. However, a total of 1647 cases of the general population have committed suicide as of 27th June 2020 after the lockdown, which on average is 25% higher as compared to the pre-lockdown period [34]. Further studies are required to recuperate the magnitude of suicide among healthcare workers.

Expectedly, the findings from this study will help refine our understanding of the influence of the COVID-19 pandemic on psychological health among different groups of health service providers and highlight the need for appropriate implementation of plans that will help prevent and manage the distress among health service providers in the current pandemic. Moreover, for short term psychological problems like anxiety, depression, and insomnia, evidence-based psychosocial interventions and support are of utter necessity at the current stage [22].

Limitation

Special consideration should be given while interpreting the data as the study had several limitations. In this online survey, a self-reported questionnaire was used and conducted in a nation where internet penetration is only 57% [35]. The use of cross-sectional data limits controls over unobserved heterogeneity among the respondents. It was a nationwide study where only a limited number of participants were involved. So, the sample may not necessarily be a good representation of the whole country and the generalizability of finding is limited. Also, there may be potential changes in distress with the progression of pandemic due to increasing number of cases and mortality. Majority of our participants were young and we did not evaluate the work experience of these young professionals. Lack of adequate work experience might have led to more distress. However, we could not determine these association of participant’s working experience with distress due to lack of data on work experience. This might be explained by the fact that our survey was online web-based which were easier to fill by young medical professionals due to their technical expertise, easy access and widespread use compared to old medical professionals.

Conclusions

This was a nationwide, web-based, cross-sectional study conducted to assess the psychological impact of COVID-19 and its associated factors among different healthcare workers in Nepal. More than half of health workers were categorized as having ‘mild-to-severe distress’ due to the COVID-19 pandemic. Female participants and doctors were having significantly more distress. The findings from the present study may highlight the need for constructing and implementing appropriate plans and policies by relevant stakeholders that will help to mitigate the distress among health service providers in the current pandemic so that we can have an efficient frontline health workforce to tackle this worse situation.

Supporting information

S1 File. Questionnaire and supplement table.

(DOCX)

Acknowledgments

We would like to acknowledge Binaya Subedi, Pujan K.C. and Matrika Dhital for their assistance in Google form dissemination in social media and also to all the participants for their active response.

Data Availability

All relevant data are within the manuscript and its Supporting information files.

Funding Statement

The author(s) received no specific funding for this work.

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Decision Letter 0

Simone Savastano

14 Dec 2020

PONE-D-20-34279

Psychological Distress among Health Service Providers during COVID-19 Pandemic in Nepal

PLOS ONE

Dear Dr. Dhan Bahadur Shrestha

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

Albeit nice and potentially interesting this study has some important limitations as highlighted by the two reviewers.

I hope Authors could be able to handle them in order to improve the quality of the manuscript and  the clarity of the message they want to give.

Please submit your revised manuscript by Jan 28 2021 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at plosone@plos.org. When you're ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file.

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If you would like to make changes to your financial disclosure, please include your updated statement in your cover letter. Guidelines for resubmitting your figure files are available below the reviewer comments at the end of this letter.

If applicable, we recommend that you deposit your laboratory protocols in protocols.io to enhance the reproducibility of your results. Protocols.io assigns your protocol its own identifier (DOI) so that it can be cited independently in the future. For instructions see: http://journals.plos.org/plosone/s/submission-guidelines#loc-laboratory-protocols

We look forward to receiving your revised manuscript.

Kind regards,

Simone Savastano

Academic Editor

PLOS ONE

Additional Editor Comments

Albeit nice and potentially interesting this study has some important limitations as highlighted by the two reviewers.

I hope Authors could be able to handle them in order to improve the quality of the manuscript and the clarity of the message they want to give.

Journal requirements:

When submitting your revision, we need you to address these additional requirements.

1. Please ensure that your manuscript meets PLOS ONE's style requirements, including those for file naming. The PLOS ONE style templates can be found at

https://journals.plos.org/plosone/s/file?id=wjVg/PLOSOne_formatting_sample_main_body.pdf and

https://journals.plos.org/plosone/s/file?id=ba62/PLOSOne_formatting_sample_title_authors_affiliations.pdf

2.The text in Figure 1 is hard to read. Please increase the size of the font.

[Note: HTML markup is below. Please do not edit.]

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Partly

Reviewer #2: Yes

**********

2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: I Don't Know

Reviewer #2: Yes

**********

3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

**********

4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

**********

5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: The study raises several major comments and concerns.

1. The measurements of the prevalence of peritraumatic distress related to COVID-19 may be

influenced by the timing of the assessment with respect to the temporal evolution of the

pandemic. Specifically, the study was conducted in October 2020, i.e., several months after

the first outbreak. There is no mention of the potential changes and/or temporal evolution of

psychological distress over time and how it could have been influenced the main findings.

Do coping mechanisms develop over time or does the burden increase as the pandemic

progresses?

2. Another critical issue is that the setting of the study is unclear, i.e., “hospitals”, “higher

centers”, “health posts” are generic denominations. It is obvious that COVID-19-related

psychological distress is clearly influenced by the fact that healthcare workers have to deal

(or not) to patients with COVID-19. Was the study specifically focusing on workers who

had to care for this patient group or not? Importantly, the severity of COVID-19 is highly

variable (from asymptomatic cases to those in need of ICU admission). Thus, it is

conceivable that people who have to care to ICU cases are more scared and distressed than

those working in a general ward where patients with less severe disease are admitted.

3. How is it possible to claim that the pandemic has heightened the psychological distress

amongst health care service providers? While this is quite expected, the use of CPDI is

focused on COVID-19-related distress and broader implications (i.e., “the psychological

distress”) are unwarranted and not grounded in the study results.

4. The CPDI was developed in China; was it validated in the Nepalese population? Are

psychometric properties of the Nepalese version satisfactory?

5. Most participants were very young. Does working experience mitigate the psychological

distress elicited by COVID-19?

Minor points

1. Avoid mentioning statistical software in the “Abstract” section.

2. “ Gender” is a psychosocial construct; consider “sex” instead. Please also replace “female”

and “male” with “women” and “men”, respectively.

Reviewer #2: The study is well written and it focuses on an important aspect of the pandemic which has affected entire health care systems. However, there are several issues that have to be clarified. First of all, the vast majority of the population is less than 30 years old and this may not represent the overall population within the health care system. Second, the institute categories are not well specified especially when considering that the specific conditions in which employees work can affect their psychological distress regardless of the pandemic. Moreover, it's not clear whether all the participants worked directly with COVID-19 patients or not or how this distress level compares to pre-pandemic surveys of healthcare workers.

**********

6. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: Yes: Benedetta Vanini

Reviewer #2: No

[NOTE: If reviewer comments were submitted as an attachment file, they will be attached to this email and accessible via the submission site. Please log into your account, locate the manuscript record, and check for the action link "View Attachments". If this link does not appear, there are no attachment files.]

While revising your submission, please upload your figure files to the Preflight Analysis and Conversion Engine (PACE) digital diagnostic tool, https://pacev2.apexcovantage.com/. PACE helps ensure that figures meet PLOS requirements. To use PACE, you must first register as a user. Registration is free. Then, login and navigate to the UPLOAD tab, where you will find detailed instructions on how to use the tool. If you encounter any issues or have any questions when using PACE, please email PLOS at figures@plos.org. Please note that Supporting Information files do not need this step.

PLoS One. 2021 Feb 10;16(2):e0246784. doi: 10.1371/journal.pone.0246784.r002

Author response to Decision Letter 0


29 Dec 2020

Joerg Heber,

Editor in Chief, PLOS ONE

Dear Dr. Heber,

Thank you for your interest in our manuscript: PONE-D-20-34279, Psychological Distress among Health Service Providers during COVID-19 Pandemic in Nepal. We are grateful to the editors for allowing us to revise our manuscript. We responded to the reviewer’s comments and concerns, and believe our manuscript is clearer and of greater quality as a result.

Below we repeat each of the comments from the referees in bold italics followed by our responses in plain text with yellow highlights.

Journal requirements:

When submitting your revision, we need you to address these additional requirements.

1. Please ensure that your manuscript meets PLOS ONE's style requirements, including those for file naming. The PLOS ONE style templates can be found at

https://journals.plos.org/plosone/s/file?id=wjVg/PLOSOne_formatting_sample_main_body.pdf and

https://journals.plos.org/plosone/s/file?id=ba62/PLOSOne_formatting_sample_title_authors_affiliations.pdf

Reply: We have amended in manuscript text.

2. The text in Figure 1 is hard to read. Please increase the size of the font.

Reply: We have amended in manuscript text.

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Partly

Reviewer #2: Yes

________________________________________

2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: I Don't Know

Reviewer #2: Yes

________________________________________

3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

________________________________________

4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

________________________________________

5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: The study raises several major comments and concerns.

1. The measurements of the prevalence of peritraumatic distress related to COVID-19 may be influenced by the timing of the assessment with respect to the temporal evolution of the pandemic. Specifically, the study was conducted in October 2020, i.e., several months after the first outbreak. There is no mention of the potential changes and/or temporal evolution of psychological distress over time and how it could have been influenced the main findings.

Do coping mechanisms develop over time or does the burden increase as the pandemic

progresses?

Reply: Distress severity is contrasted in discussion section. In similar survey in Nepalese residents using CDPI in early phase of pandemic showed distress in only 11%. While present survey showed significantly higher number of participants having distress, could be being this survey was only among health professional who has risk of contracting the infection and next may be due to evolution of pandemic.

2. Another critical issue is that the setting of the study is unclear, i.e., “hospitals”, “higher

centers”, “health posts” are generic denominations. It is obvious that COVID-19-related

psychological distress is clearly influenced by the fact that healthcare workers have to deal (or not) to patients with COVID-19. Was the study specifically focusing on workers who had to care for this patient group or not? Importantly, the severity of COVID-19 is highly variable (from asymptomatic cases to those in need of ICU admission). Thus, it is

conceivable that people who have to care to ICU cases are more scared and distressed than those working in a general ward where patients with less severe disease are admitted.

Reply: This is detailed in methods sections in revision. Available data about institution and type of job is presented in table 1 of result section.

3. How is it possible to claim that the pandemic has heightened the psychological distress amongst health care service providers? While this is quite expected, the use of CPDI is focused on COVID-19-related distress and broader implications (i.e., “the psychological distress”) are unwarranted and not grounded in the study results.

Reply: Result of similar study regarding psychological distress in Nepalese community is contrasted in discussion. In prior study, may be due to early phase of pandemic distress level was relatively low in Nepal comparing with other countries, which were already in mid-later phase of pandemic. In present study, we found significantly higher proportion of health professionals with distress suggesting towards its relation with development of pandemic.

4. The CPDI was developed in China; was it validated in the Nepalese population? Are

psychometric properties of the Nepalese version satisfactory?

Reply: CPDI is widely under use due to its COVID-19 specific nature. In several studies carried out in Nepal and other countries are using it due to its specific nature. In our case we checked internal consistency of 24 CPDI variables using Cronbach's α. Its internal reliability was found to be 0.905 indicating high internal consistency of the scale.

5. Most participants were very young. Does working experience mitigate the psychological distress elicited by COVID-19?

Reply: We have explained in limitation section in discussion.

Minor points

1. Avoid mentioning statistical software in the “Abstract” section.

Reply: We have amended in manuscript text.

2. “Gender” is a psychosocial construct; consider “sex” instead. Please also replace “female” and “male” with “women” and “men”, respectively.

Reply: We have amended in manuscript text.

Reviewer #2: The study is well written and it focuses on an important aspect of the pandemic which has affected entire health care systems. However, there are several issues that have to be clarified. First of all, the vast majority of the population is less than 30 years old and this may not represent the overall population within the health care system. Second, the institute categories are not well specified especially when considering that the specific conditions in which employees work can affect their psychological distress regardless of the pandemic. Moreover, it's not clear whether all the participants worked directly with COVID-19 patients or not or how this distress level compares to pre-pandemic surveys of healthcare workers.

Reply: Amended, These issues discussed in method section and limitation section.

________________________________________

Thank you for your consideration. We look forward to hearing from you.

Sincerely,

Dhan Bahadur Shrestha

Mangalbare Hospital, Morang, Nepal

Attachment

Submitted filename: Rebuttal letter.docx

Decision Letter 1

Simone Savastano

27 Jan 2021

Psychological Distress among Health Service Providers during COVID-19 Pandemic in Nepal

PONE-D-20-34279R1

Dear Dr. Dhan Bahadur Shrestha

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

An invoice for payment will follow shortly after the formal acceptance. To ensure an efficient process, please log into Editorial Manager at http://www.editorialmanager.com/pone/, click the 'Update My Information' link at the top of the page, and double check that your user information is up-to-date. If you have any billing related questions, please contact our Author Billing department directly at authorbilling@plos.org.

If your institution or institutions have a press office, please notify them about your upcoming paper to help maximize its impact. If they’ll be preparing press materials, please inform our press team as soon as possible -- no later than 48 hours after receiving the formal acceptance. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information, please contact onepress@plos.org.

Kind regards,

Simone Savastano

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #1: All comments have been addressed

Reviewer #2: All comments have been addressed

**********

2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: (No Response)

Reviewer #2: Yes

**********

3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: (No Response)

Reviewer #2: Yes

**********

4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

**********

5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

**********

6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: (No Response)

Reviewer #2: All the comments have been addressed except the comparison of the distress level with pre-pandemic surveys of healthcare workers. However, this could be an option for a future study in order to strenghten the results founded in this paper.

**********

7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: Yes: benedetta vanini

Reviewer #2: No

Acceptance letter

Simone Savastano

29 Jan 2021

PONE-D-20-34279R1

Psychological distress among health service providers during COVID-19 pandemic in nepal

Dear Dr. Shrestha:

I'm pleased to inform you that your manuscript has been deemed suitable for publication in PLOS ONE. Congratulations! Your manuscript is now with our production department.

If your institution or institutions have a press office, please let them know about your upcoming paper now to help maximize its impact. If they'll be preparing press materials, please inform our press team within the next 48 hours. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information please contact onepress@plos.org.

If we can help with anything else, please email us at plosone@plos.org.

Thank you for submitting your work to PLOS ONE and supporting open access.

Kind regards,

PLOS ONE Editorial Office Staff

on behalf of

Dr. Simone Savastano

Academic Editor

PLOS ONE

Associated Data

    This section collects any data citations, data availability statements, or supplementary materials included in this article.

    Supplementary Materials

    S1 File. Questionnaire and supplement table.

    (DOCX)

    Attachment

    Submitted filename: Rebuttal letter.docx

    Data Availability Statement

    All relevant data are within the manuscript and its Supporting information files.


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