Pyogenic Ventriculitis Associated with Urosepsis: A Rare Case Report

Abstract

Pyogenic ventriculitis is an infection of the cerebral ventricles usually associated with neurosurgery or head trauma. There are less than 10 reported cases of community-acquired pyogenic ventriculitis in adults. We present the case of a 71-year-old man with a medical history of type 2 diabetes mellitus, hospitalized due to urosepsis caused by E. coli. Because he had a fluctuant level of consciousness, he underwent magnetic resonance imaging that diagnosed pyogenic ventriculitis. He was treated with ceftriaxone 2 g 12/12h for a total of 6 weeks and recovered without neurological deficits. Pyogenic ventriculitis is a clinical challenge due to its rarity, atypical presentation and variety of aetiological microorganisms.

LEARNING POINTS

• Pyogenic ventriculitis is an infection of the cerebral ventricles usually associated with neurosurgery or head trauma; community-acquired primary pyogenic ventriculitis is very rare.

• Presentation is atypical (no meningism), multiple microorganisms can be involved, and it should be treated with prolonged antibiotic regimens.

• MRI is the most useful exam for diagnosis.

CASE DESCRIPTION

We present the case of a 71-year-old male patient, still professionally active, with a medical history of type 2 diabetes mellitus with poor metabolic control, who was admitted to the emergency department with symptoms of nausea, vomiting, dysuria and fever. A diagnosis of pyelonephritis was made and the patient was discharged with a prescription for amoxicillin-clavulanic acid. Over the next few days, in addition to the previous symptoms, a change in the patient’s behaviour and cognition was noticed, so he returned to hospital. At this second presentation, he was confused and had a fever (temperature 39ºC), but there were no other abnormalities in his physical examination, as there was no alteration in his cardio-pulmonary auscultation, no neurological deficits and no meningeal signs. He denied any recent travel, head trauma or previous neurosurgery. His laboratory results revealed leucocytosis, elevated C-reactive protein, altered renal function and leukocyturia (Table 1). A renal CT scan showed kidneys with multiple simple cysts and inflammatory signs. While in the emergency department, the patient’s level of consciousness declined from a Glasgow Coma Scale (GCS) score of 14 to 7, so he was admitted to the internal medicine department with a diagnosis of urosepsis and was prescribed ceftriaxone 2 g, 24/24h.

Table 1.

Blood tests at admission to the emergency room

Haemoglobin	140 g/l
Platelet count	91×109/l
White blood cell count	21.8×109/l (94% neutrophils)
Glucose	97 mg/dl
Urea	100 mg/dl
Creatinine	3.0 mg/dl
Sodium	136 mmol/l
Potassium	4.5 mmol/l
CRP	45.18 mg/dl
HIV 1 and 2	Negative
Urinalysis	500 leukocytes/μl; negative nitrite

In his first days in hospital, he was agitated and disoriented but his physical examination showed no new findings and he was apyretic. There was a slow reduction in inflammatory parameters and a multisensitive E. coli grew in blood and urine cultures.

By the fourth day of hospitalization, the fever had returned and his mental status became fluctuant: one hour he had a GCS score of 14 and the next hour he had a GCS score of 7. His physical examination revealed new nuchal and inferior member rigidity, so a lumbar puncture was performed (Table 2) and a cranial CT scan was ordered. The CT scan had no relevant alterations, so we proceeded to an MRI. This latter exam showed purulent collections in the lateral ventricles and occipital horns suggestive of pyogenic ventriculitis (Fig. 1).

Table 2.

Cerebrospinal fluid analysis

Aspect	Clear
Total protein	82 mg/dl
Glucose	76 mg/dl
Blood glucose at the time	300 mg/dl
Cell count	24 cells/μl (mononuclear cells predominantly)
Culture	Sterile
Sodium	136 mmol/l

Figure 1.

Magnetic resonance imaging, DWI sequences (arrows point to the pus in the ventricles)

A multidisciplinary discussion followed, and it was decided that the patient did not need surgery as there was no hydrocephaly, but that the antibiotic regimen should be changed to ceftriaxone 2 g, 12/12h. A transoesophageal echocardiogram ruled out endocarditis as a septic emboli source.

On the 25th day, the MRI was repeated and showed the purulent foci were significantly smaller. The antibiotic regimen was maintained for 6 weeks and by the end of this period the patient was oriented, still a little confused, but well enough to be discharged. A long and difficult rehabilitation process followed, but 6 months after discharge the patient had returned to his previous autonomy with no neurological sequelae. As a new physical finding, he presented Beau lines in his finger nails (Fig. 2).

Figure 2.

Beau lines

DISCUSSION

Pyogenic ventriculitis is a bacterial infection of the cerebral ventricles more commonly associated with head trauma or neurosurgery and neurosurgical devices. Although rare, it can also present as a complication of meningitis or cerebral abscess in adults. To date less than 10 cases of adult community-acquired primary pyogenic ventriculitis have been published, all in the last 10 years, probably because of the increasing use of MRI ^[1].

Primary pyogenic ventriculitis cases appear to be more common in the elderly (mean age of 65 years) and to present with no meningism^[1,2]. In all published cases, MRI was essential for the diagnosis and CT scans were normal or had ventricle collections that could not be differentiated between blood and pus. Bacterial agents were varied as were the antibiotic regimens chosen, and some patients needed neurosurgical drainage ^[2]. Diabetes seems to be a common risk factor owing to its immunosuppressive role ^[3].

MRI is the most useful exam in the diagnosis of pyogenic ventriculitis, with the most characteristic finding being the presence of purulent debris with an irregular outline in the interior of the cerebral ventricles. This material presents as hyperintense in T1 sequences and hypointense in T2 sequences, but it is even more evident in diffusion-weighted imaging (DWI) sequences ^[3].

In a literature review, we found only two cases similar to that presented here. In both these cases the initial diagnosis was urinary infection, but an altered mental status led to a subsequent study, with pyogenic ventriculitis being diagnosed. As in our case, E. coli was the bacterial agent implied as it grew on blood, urine and cerebrospinal fluid cultures ^{[4, 5]}. We could only isolate E. coli in blood and urine cultures, probably because the patient was already on his fifth day of antibiotic, so we think it is reasonable to assume that the agent responsible for the pyogenic ventriculitis was E. coli.

We used an antibiotic regimen of ceftriaxone 2 g, 12/12h (the so called ‘meningeal dose’) for 6 weeks, even though there were no clinical guidelines to support it. In the two cases similar to ours, this was also the antibiotic regimen chosen, also with a good outcome [4, 5]. The few cases published and the multitude of microorganisms implicated make it difficult to generate a universal recommendation, but the consensus seems to be to use long antibiotic regimens ^{[1, 6]}.

The atypical clinical manifestations and variety of bacterial organisms involved make suspicion of pyogenic ventriculitis less likely. In a patient with an altered mental status, MRI is the most useful exam to diagnose this clinical condition as it shows specific abnormalities that cannot be differentiated in a CT scan ^{[1–3, 5]}.