Fig. 8.

ha-MSC loaded POx2-75 hydrogels enhanced neovascularization in the border area of MI hearts and enhanced gene expression of cardiac regenerative factors. A. Isolectin B4 staining demonstrated increased capillary density in the border area of MI + Gel and MI + Gel + Cell treatment groups compared to the MI group; scale bar, 50 μm. B. Capillaries formed inside of the POx hydrogel layer. Red, CM-Dil labelled ha-MSCS; blue, DAPI; green, Isolectin B4; scale bar, 50 μm. C. Corresponding quantification of capillary densities. MI group (N = 3), MI + Gel group (N = 4) and MI + Gel + Cell group (N = 4). D. Quantification of VCAM-1 and VEGF gene expression in different MI groups (N = 3 for each group). *p < 0.05; **P < 0.01; ****p < 0.0001. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)