FIG 3.

Genes related to oxidative stress and heme metabolism, such as Nrf2 (Nfe2l2), HO-1 (Hmox1), and Nramp1 (Slc11a1), are highly altered in the lungs of Nrf2^−/− mice following MAC infection. At 2 months after MAC infection, hierarchical clustering based on the 79 differentially expressed genes between the lungs of wild-type mice infected with MAC bacteria and those of Nrf2^−/−mice infected with MAC bacteria was done, with statistically significant differences (FDR-adjusted P < 0.01) and with more than 2-fold changes. WTC, uninfected lungs from wild-type mice; KOC, uninfected lungs from Nrf2^−/−mice; WTI, infected lungs from wild-type mice; KOI, infected lungs from Nrf2^−/−mice.