TABLE 2.
The top 15 significantly enriched canonical pathways in the lungs of Nrf2-deficient mice compared with those of wild-type mice, 2 months after MAC infection
| Ingenuity canonical pathway | P value | Gene name(s) |
|---|---|---|
| NRF2-mediated Oxidative Stress Response | 4.5E−06 | GSTA3, ACTC1, AOX1, PRDX1, HMOX1, ACTG2, NFE2L2 |
| Heme Degradation | 6.0E−05 | BLVRB, HMOX1 |
| Remodeling of Epithelial Adherens Junctions | 1.4E−03 | ACTC1, ACTN2, ACTG2 |
| Caveolar-mediated Endocytosis Signaling | 1.5E−03 | CAV1, ACTC1, ACTG2 |
| Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes | 3.5E−03 | ACTC1, HMOX1, ACTG2 |
| VEGF Signaling | 5.9E−03 | ACTC1, ACTN2, ACTG2 |
| Integrin Signaling | 6.3E−03 | CAV1, ACTC1, ACTN2, ACTG2 |
| Choline Degradation I | 6.5E−03 | CHDH |
| Virus Entry via Endocytic Pathways | 6.9E−03 | CAV1, ACTC1, ACTG2 |
| Paxillin Signaling | 7.4E−03 | ACTC1, ACTN2, ACTG2 |
| Mechanisms of Viral Exit from Host Cells | 7.8E−03 | ACTC1, ACTG2 |
| Iron Homeostasis Signaling | 9.8E−03 | CYBRD1, SLC11A1, HMOX1 |
| Phagosome Maturation | 1.2E−02 | DYNLT1, CTSK, PRDX1 |
| Epithelial Adherens Junction Signaling | 1.3E−02 | ACTC1, ACTN2, ACTG2 |
| Nicotine Degradation III | 1.4E−02 | AOX1, Aox3 |