Table 1.
Details regarding the 22 independent patient cohorts included in this systematic review.
| Author | Year | Study Type (LOE) | Country | BRCA (N) | BRCA1 | BRCA2 | BCS (N) | Mastectomy (N) | Median age (years) | Follow up (months) | NOS |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Robson | 2005 | RC (III) | US | 87 | 62 | 25 | 87 | – | 43 | 76 | 6 |
| Turner | 1999 | RC (III) | US | 8 | 5 | 3 | 8 | – | 36 | 174 | 5 |
| Garcia-Etienne | 2009 | RC (III) | Italy | 54 | 26 | 28 | 54 | – | 36 | 48 | 6 |
| Yoon | 2019 | RC (III) | Korea | 51 | 33 | 18 | 51 | – | 44 | 85 | 6 |
| Nilsson | 2014 | RC (III) | Sweden | 162 | – | – | 45 | 118 | 43 | 155 | 7 |
| Chiba | 2016 | RC (III) | US | 173 | 100 | 73 | 60 | 109 | 46 | 41 | 6 |
| Haffty | 2002 | RC (III) | US | 22 | 15 | 7 | 22 | – | 34 | 168 | 6 |
| Ye | 2020 | RC (III) | China | 63 | – | – | 63 | – | 41 | 61 | 5 |
| Van den Broek | 2018 | RC (III) | Netherlands | 261 | 190 | 71 | 125 | 136 | 39 | 40 | 6 |
| Robson | 1995 | RC (III) | US | 35 | 27 | 9 | 35 | – | – | 124 | 5 |
| Drooger | 2015 | RC (III) | Netherlands | 691 | 517 | 174 | 349 | 337 | – | 109 | 7 |
| Huang | 2020 | RC (III) | China | 176 | – | – | 44 | 132 | – | 48 | 5 |
| Pierce | 2010 | RC (III) | US | 655 | 394 | 261 | 302 | 353 | 42 | 103 | 6 |
| Kirova | 2010 | RC (III) | France | 27 | 19 | 8 | – | – | 43 | 167 | 5 |
| Pierce | 2016 | RC (III) | US | 160 | 123 | 37 | 160 | – | 40 | 95 | 6 |
| Metcalfe | 2011 | RC (III) | Canada | 396 | 259 | 142 | 396 | – | 42 | 126 | 6 |
| Brekelmens | 2007 | RC (III) | Netherlands | 260 | 90 | 170 | 111 | 135 | 43 | 52 | 6 |
| Eccles | 2001 | RC (III) | UK | 75 | 75 | – | 36 | 39 | 38 | 107 | 7 |
| El Tamer | 2004 | RC (III) | US | 51 | 30 | 21 | 21 | 30 | 48 | 79 | 6 |
| Robson | 1998 | RC (III) | US | 30 | 23 | 7 | 9 | 19 | 36 | 66 | 6 |
| Cao | 2019 | RC (III) | China | 103 | 31 | 72 | 103 | – | 45 | 80 | 6 |
| Foulkes | 1997 | RC (III) | US | 12 | 12 | – | 11 | – | 45 | 37 | 5 |
| Bernstein-Mohlo | 2020 | RC (III) | Israel | 255 | 169 | 86 | 127 | 128 | 44 | 71 | 7 |
LOE; level of evidence, N; number, BCS; breast conservation surgery, NOS; Newcastle-Ottawa Scale, RC; retrospective cohort, US; United States, UK; United Kingdom.