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. 2021 Feb 13;7(2):e06252. doi: 10.1016/j.heliyon.2021.e06252

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© 2021 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Migration of metastatic breast cancer cells was promoted by stiff matrix in a YAP-dependent manner. (A) Time-lapse microscopy images of gap closure of MCF-7, Hs 578T and MDA-MB-231 cells that were cultured on stiff (plastic) or soft (PDMS) substrates (Soft 1:5, Soft 1:10, Soft 1:20) at 0 h (Day 1) and 24 h (Day 2) after scratch was created. The dotted lines define the area lacking cells. Scale bar, 100 μm. (B) The quantification of Gap Closure Assay in Figure 3A using ImageJ. The average healing speed (μm/h) of MCF-7 (top graph), Hs 578T (middle graph) and MDA-MB-231 cells (bottom graph) was shown. Data were represented as means ± SD (n = 3). ∗P < 0.05.