Figure 1.
Oophorectomy in female LR/Stat3Δ/Δ mice increased tumor burden, and estrogen replacement rescued this effect. (a) Representative photomicrographs of the whole slide images of lung gematoxylin and eosin (H&E) stained sections (scale bar = 3 mm) and (b) Tumor/lung area percentage (n = 4–6). (c) Lung surface tumor number (n = 8–12). (d) Representative photomicrographs of Ki-67 stained sections (n = 3–4) (scale bar = 200 μm), and (e) proliferative rate presented as the percentage of Ki-67-positive cells. Data represent mean ± SEM; ***P < 0.001, **P < 0.01, *P < 0.05, experimental replicate #3.