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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Bone. 2020 Oct 3;142:115679. doi: 10.1016/j.bone.2020.115679

Table 2.

miRNA known to directly target nodes of the p53 and p16INK4a cell cycle arrest pathways confirmed via luciferase assay or similar methodology

Target Gene miRNA (and References)
p53   miR-15a (185), miR-16 (185), miR-19b (162), miR-25 (160), miR-30d (160), miR-33 (186), miR-92 (187), miR-98 (188), miR-125a (189), miR-125b (190), miR-150 (191), miR-138 (192), miR-141 (187), miR200a (193), miR-214 (194), miR-374 (195), miR-380–5p (161), miR453 (188), miR-504 (196), miR-518c* (197), miR-638 (197), miR-1285 (198), miR-3151 (199)
MDM2   miR-17–3p (150), miR-18b (200), miR-25 (149), miR-32 (149), miR-
143 (148), miR-145 (148), miR-192 (201), miR-193a (202), miR-194 (201), miR-215 (201), miR-221 (203), miR-339–5p (166), miR-509–5p
(204), miR-605 (205), miR-660 (206), miR-661 (207)
SIRT1   miR-9 (208), miR-22 (173), miR-34a (115, 171), miR-100 (209), miR132–3p (210), miR-135a (84), miR-137 (209), miR-138 (175), miR-143
(211), miR-145 (211), miR-181a (175), miR-181b (175), miR-181c (208), miR-195 (78), miR-199a (212), miR-199b (84), miR-200a (213), miR-204 (84), miR-217 (174), miR-449a (172, 214), miR-486–5p (82)
p21   miR-17 (73), miR-17–5p (74), miR-18a (74), miR-20a (73, 76), miR20b (74), miR-93 (74, 75), miR-106a (74, 215), miR-106b (74, 75,
163), miR-302a (163), miR-372 (74), miR-663 (165)
p16INK4a   miR-24 (140, 141), miR-31 (216), miR-877–3p (167)
BMI1   miR-128a (217), miR-141 (97, 98), miR-194 (218), miR-218 (219), miR-487b (220), miR-495 (87)
CBX7   miR-9 (221), miR-125b (222), miR-181a (222, 223), miR-181b (222)
EZH2   miR-26a (224, 225), miR-26b (223), miR-101 (226, 227), miR-137 (228), miR-138 (229), miR-210 (223), miR-365 (230)
EED   miR-26b (223), miR-101 (227), miR-210 (223), miR-424 (223)
SUZ12   miR-210 (223), miR-424 (223), miR-487b (220), miR-489 (231), miR767–5p (232)
Cyclin D   miR-15b (233, 234), miR-34b (235), miR-34c (235), miR-188 (107), miR-195 (236), miR-449a (168, 235), miR-490–3p (237), miR-503 (238)
Cyclin E   miR-15b (233, 234), miR-188 (107)
CDK2   miR-31 (131), miR-188 (107)
CDK4   miR-188 (107)
CDK6   miR-200a (239), miR-449a (240), miR-449b (240)
pRb   miR-17 (176), miR-17–5p (241), miR-20a (176), miR-106b (176)
E2F1   miR-17–5p (242), miR-20a (242, 243), miR-205 (169), miR-331–3p (244), miR-493 (245)
E2F2   miR-20a (242, 243), miR-21 (135), miR-34b (235), miR-34c (235), miR-218 (246), miR-449a (235)
E2F3   miR-20a (242, 243), miR-34b (235), miR-34c (235),
miR-203 (170), miR-203a (247), miR-210 (248), miR-214 (249), miR-449a (235), miR-503 (238), miR-577 (250)
E2F5   miR-154 (251)