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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Gut. 2020 Aug 25;70(4):666–676. doi: 10.1136/gutjnl-2019-320135

Figure 6.

Figure 6

ANG1 treatment reverses dysbiosis and suppresses DSS-induced colitis in Ang1−/− mice. (A) Scheme of oral ANG1 treatment in Ang1−/− mice for analysing its preventive potential. (B) Body weight of vehicle-treated or ANG1-treated Ang1−/− mice during DSS-induced colitis, n=7. (C–E) Colon length (C), DAI (D) and histological score (E) of vehicle-treated or ANG1-treated Ang1−/− mice on day 9 after DSS induction, n=7. Scale bar, 50 μm. (F) The relative abundance of indicated bacterium in vehicle-treated or ANG1-treated Ang1−/− mice. The heatmap represents the relative bacterial abundance in each mouse after normalised to the average of ANG1 group, n=7. Data are presented as mean±SEM; *p<0.05; **p<0.01 by unpaired Student’s t-test (B–E). ANG, angiogenin; DSS, dextran sodium sulphate.