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. 2021 Jan 26;96(4):e538–e552. doi: 10.1212/WNL.0000000000011210

Figure 2. Infantile Parenchymal Abnormalities in Patients With ACTA2 Arg179.

Figure 2

Diffusion-weighted imaging (DWI) and T2- and T1-weighted (T2W, T1W) sequences of 4 patients with ACTA2 Arg179 pathogenic variants aged 2, 10, 66, and 110 days. Right: Follow-up fluid-attenuated inversion recovery (FLAIR) sequences of the same patients of each row at 7.2, 7.1, 1.2, and 1.8 years of age. All patients show acute DWI lesions consistent with internal border zone infarctions. White matter corresponding to acute DWI lesions shows T2W-hypointense and T1W-hyperintense, mostly ring-like signal abnormalities (black arrows). Note highlighted similar shapes of the edges of acute DWI lesions and of long-term follow-up white matter hyperintensities on FLAIR sequences (white arrows). The patient in row 4 had additional hemodynamic ischemic strokes (black asterisks) due to complications during heart surgery in addition to deep white matter lesions.