Corrigendum: Dual-Targeting Nanoparticle-Mediated Gene Therapy Strategy for Hepatocellular Carcinoma by Delivering Small Interfering RNA

In the published article, there was an error in affiliations 1 and 2. Affiliation 1 should be “Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China”. Affiliation 2 should be “Department of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan, China”.

In the original article, there was a mistake in the Graphical Abstract and in Figure 1 as published. “EPR effect” was incorrectly written as “ERP effect”. The corrected Graphical Abstract and Figure 1 appear below.

Graphical Abstract.

Figure 1.

Schematic representation of GCGA–siPAK1 promoting targeted delivery and therapeutic efficacy in HCC xenograft mouse model. The process includes four steps: (1) intravenous administration of GCGA–siPAK1 via tail vein; (2) NPs accumulation in tumor tissue via passive targeting (commonly known as the EPR effect); (3) three modalities of active targeting via dual-ligand-receptor-mediated endocytosis and mechanism of RNAi (siPAK1-induced PAK1 silencing); (4) tumor biological behaviors after PAK1 silencing; and (5) molecular mechanism of promoting cell apoptosis via PAK1/MEK/ERK pathway.

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.