TABLE 3.

Biochemical Measurements from UGT1A1 c.222CA Homozygotes Under Phototherapy or Post–Liver Transplantation

		Phototherapy (N = 28)*					After Liver Transplantation (N = 17)
Serum Measurement	Reference Range	N†	Mean ± 1 SD	Median	Range	CV	N	Mean ± 1 SD	Median	Range	CV	P	F (P)‡
Total bilirubin, mg/dL	<0.8	627	17.0 ± 5.9	16.0	3.7-39.0	36%	113	0.9 ± 1.0	0.7	0.2-9.8	108%	<0.0001	34.8 (<0.0001)
(μmol/L)	(<14)		(278 ± 100)	(274)	(63-667)			(15 ± 17)	(12)	(3-168)
Albumin, g/dL	3.7-5.6	475	4.2 ± 0.5	4.2	2.8-6.7	12%	90	4.2 ± 0.4	4.3	3.3-5.5	9%	ns	1.6 (0.0106)
(μmol/L)	(559-846)		(627 ± 77)	(634)	(420-1,012)			(638 ± 57)	(649)	(498-831)
Bilirubin–albumin ratio, mol:mol	—	475	0.47 ± 0.17	0.47	0.10-1.51	35%	76	0.02 ± 0.03	0.02	0.01-0.26	130%	<0.0001	28.4 (<0.0001)
Alanine aminotransferase, U/L	10-45	401	75 ± 46	66	8-333	61%	134	52 ± 126	29	10-1,427	242%	0.0405	7.5 (<0.0001)
Alkaline phosphatase, U/L	120-488	384	217 ± 60	218	38-420	28%	94	93 ± 62	76	29-469	67%	<0.0001	1.1 (ns)
Gamma-glutamyltransferase, U/L	2-39	302	33 ± 36	23	3-393	111%	125	51 ± 61	25	7-289	120%	0.0024	2.9 (<0.0001)

^*The “phototherapy” group is made up of all 28 UGT1A1 c.222C>A homozygotes; the “post–liver transplantation” group is made up of 17 of those same individuals after they received a liver transplant.

^†“N” represents the number of individual laboratory values analyzed from patients treated with phototherapy (n = 28) as compared with liver transplantation (n = 17).

^‡F is the ratio of SDs squared. P represents the P value for the F ratio; it measures the probability that the SDs (i.e., variance between populations) are the same.

Abbreviations: CV, coefficent of variation; na, not applicable; ns, not significant (ANOVA P > 0.05).