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. 2021 Jan 26;10(2):239. doi: 10.3390/cells10020239

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Epstein–Barr virus (EBV) isoform interaction with p53. The EBV spliced isoforms EBNA3C and the transcription factor BZFL1 both interact with p53 to induce oncogenic transformation such as apoptosis, inhibiting the transcriptional activity and degradation of p53 [62,63].