Figure 4.

Body mass (a,b), plasma alanine aminotransferase (ALT) (c), HOMA-IR (d,e), and plasma non-esterified fatty acids (NEFA) (f) and triglycerides (g) of male and female middle-aged mice following 6 weeks of receiving a control- (Veh; vehicle) or BYL719 (BYL)-containing diet. Data are presented as mean ± SE, statistical analysis for was by two-way repeated measures ANOVA (a,b) and two-way ANOVA (d,e) with a Sidak post-hoc and/or t-test (c,f,g). ** p < 0.01, *** p < 0.001, **** p < 0.0001 vs. Veh, n = 6 per group for (a–d).