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Rotarod (a) and hang time performance (b), novel and familiar object sniffing time (novel object test, c,d), time spent in inner and outer zone (e,f) and total movement distance (g,h) during open field test for middle-aged male and female mice after receiving a control- (Veh; vehicle) or BYL719 (BYL)-containing diet. Data are presented as mean ± SE, statistical analysis was by t-test (a,b,g,h) or two-way ANOVA with Sidak post-hoc (c–f).
